Development of idiosyncratic hepatotoxicity is an intricate process involving both concurrent
as well as sequential events determining the direction of the pathways, degree of liver injury …

The cornerstone of tuberculosis management is a 6‐month course of isoniazid, rifampicin,
pyrazinamide and ethambutol. Compliance is crucial for curing tuberculosis. Adverse effects …

Os objetivos principais do tratamento da tuberculose são curar o paciente e minimizar a
possibilidade de transmissão do bacilo para indivíduos saudáveis. Reações adversas ou …

Isoniazid, pyrazinamide and rifampicin have hepatotoxic potential, and can lead to such
reactions during antituberculosis chemotherapy. Most of the hepatotoxic reactions are dose …

Background Pyrazinamide (PZA) is a common drug that causes serious adverse events
(SAEs). The aim of this study was to determine the incidence of and risk factors for SAEs due …

Mycobacterium tuberculosis (MTB) causes substantial morbidity and mortality in liver
transplant recipients. We examined the efficacy of isoniazid latent Mycobacterium …

Background Tuberculosis (TB) and chronic Hepatitis B virus (HBV) infection are common in
China. Fist-line anti-TB medications often produce drug-induced liver injury (DILI). This study …

Background Drug-induced liver injury (DILI) is a common complication of tuberculosis
treatment. We utilised data from the REMoxTB clinical trial to describe the incidence of …

Abstract Background and Aim Worldwide anti‐tuberculosis (TB) drug‐induced liver disease
(DILI) is an important cause of hepatotoxicity, and drug‐induced acute liver failure (ALF) …

Background The risk of anti-tuberculosis (TB) drug-induced liver injury (DILI) in patients with
chronic viral hepatitis (CVH) is not clear. The aim of this study was to investigate incidence …