Inherited mutations in the Prion protein (PrP), encoded by the PRNP gene, have been
associated with autosomal dominant neurodegenerative disorders, such as Creutzfeldt …

The cellular prion protein PrP C was identified over twenty-five years ago as the normal
counterpart of the scrapie prion protein PrP Sc, itself the main if not the sole component of …

A promising trend in tissue engineering is using biomaterials to improve the control of drug
concentration in targeted tissue. These vehicular systems are of specific interest when the …

The cellular prion protein (PrPC) has been implicated in several neurodegenerative
diseases as a result of protein misfolding. In humans, prion disease occurs typically with a …

Unveiling the events leading to the formation of prion particles is a nowadays challenge in
the field of neurochemistry. Pathogenic mutants of prion protein (PrP) are characterized by …

Prion protein (PrP) is highly conserved and is expressed in most tissues in a developmental
stage-specific manner. Glycosylated cellular prion protein (PrPC) is found in most cells and …

Neurodegenerative disorders are characterized by synaptic and neuronal dysfunction which
precedes general neuronal loss and subsequent cognitive or behavioral anomalies …

We computationally predicted all phosphorylation sites in the sequence of the human
laminin γ1-chain (LAMC1), and computationally identified, for the first time, all kinases for …

A multilayered computational workflow was designed to identify a druggable binding site on
the surface of the E200K pathogenic mutant of the human prion protein, and to investigate …

Cellular prion protein (Pr PC) is widely expressed and displays a variety of well‐described
functions in the central nervous system (CNS). Mutations of the PRNP gene are known to …