As one of the most successful therapeutic target families, G protein-coupled receptors
(GPCRs) have experienced a transformation from random ligand screening to knowledge …

Chemotactic cytokines—chemokines—control immune cell migration in the process of
initiation and resolution of inflammatory conditions as part of the body's defense system …

GPCRs are master regulators of cell signaling by transducing extracellular stimuli into the
cell via selective coupling to intracellular G-proteins. Here we present a computational …

Drought stress linked with climate change is one of the major constraints faced by common
bean farmers in Africa and elsewhere. Mitigating this constraint requires the selection of …

CCR7, collaborated with its ligands CCL19 and CCL21, controls extensive migratory events
in the immune system. CCR7-bearing dendritic cells can swarm into T-cell zones in lymph …

Numerous processes contribute to the regulation of G protein–coupled receptors (GPCRs),
but relatively little is known about rapid mechanisms that control signaling on the seconds …

Abstract Background Discover possible Drug Target Interactions (DTIs) is a decisive step in
the detection of the effects of drugs as well as drug repositioning. There is a strong incentive …

The G-protein coupled receptors (GPCRs) superfamily comprise similar proteins arranged
into families or classes thus making it one of the largest in the mammalian genome. GPCRs …

Enzymatic and cellular signalling biosensors are used to decipher the activities of complex
biological systems. Biosensors for monitoring G protein‐coupled receptors (GPCRs), the …

A variety of G protein-coupled receptors (GPCRs) have been implicated in the pathogenesis
of pulmonary fibrosis, largely through their promotion of profibrotic fibroblast activation. By …