The cyclin/CDK inhibitor p57Kip2 belongs to the Cip/Kip family, with p21Cip1 and p27Kip1,
and is the least studied member of the family. Unlike the other family members, p57Kip2 has …

How to generate a brain of correct size and with appropriate cell-type diversity during
development is a major question in Neuroscience. In the developing neocortex, radial glial …

Mosaic analysis with double markers (MADM) offers one approach to visualize and
concomitantly manipulate genetically defined cells in mice with single-cell resolution. MADM …

Major depressive disorder (MDD) is a prevalent and devastating mental illness. To date, the
diagnosis of MDD is largely dependent on clinical interviews and questionnaires and still …

In mammalian genomes, a subset of genes is regulated by genomic imprinting, resulting in
silencing of one parental allele. Imprinting is essential for cerebral cortex development, but …

Abstract GATAD2B (GATA zinc finger domain containing 2B) variants are associated with
the neurodevelopmental syndrome GAND, characterized by intellectual disability (ID) …

Tissue clearing renders entire organs transparent to accelerate whole-tissue imaging; for
example, with light-sheet fluorescence microscopy. Yet, challenges remain in analyzing the …

Understanding the generation of complexity in living organisms requires the use of lineage
tracing tools at a multicellular scale. In this review, we describe the different multicolor …

Cyclin-dependent kinases (CDKs) and their inhibitors (CDKIs) play pivotal roles in the
regulation of the cell cycle. As a result of these functions, it may be extrapolated that they are …

Concerted radial migration of newly born cortical projection neurons, from their birthplace to
their final target lamina, is a key step in the assembly of the cerebral cortex. The cellular and …