The yeast Saccharomyces cerevisiae has been a favorite organism for pioneering studies
on nutrient-sensing and signaling mechanisms. Many specific nutrient responses have been …

Ever since the beginning of biochemical analysis, yeast has been a pioneering model for
studying the regulation of eukaryotic metabolism. During the last three decades, the …

The cell tropism of human noroviruses and the development of an in vitro infection model
remain elusive. Although susceptibility to individual human norovirus strains correlates with …

Yeast cells sense the amount and quality of external nutrients through multiple
interconnected signaling networks, which allow them to adjust their metabolism …

The nuclear envelope is a double membrane that separates the nucleus from the cytoplasm.
The inner nuclear membrane (INM) functions in essential nuclear processes including …

Numerous nascent proteins undergo folding and maturation within the luminal and
membrane compartments of the endoplasmic reticulum (ER). Despite the presence of …

Misfolded proteins in the endoplasmic reticulum (ER) are eliminated by a quality control
system called ER-associated protein degradation (ERAD). However, it is unknown how …

Nitrogen is one of the most important essential nutrient sources for biogenic activities.
Regulation of nitrogen metabolism in microorganisms is complicated and elaborate. For this …

To enter the nucleus a protein must be chaperoned by a transport factor through the nuclear
pore complex or it must be small enough to pass through by diffusion. Although these …

The nuclear envelope (NE) is a specialization of the endoplasmic reticulum with distinct
biochemistry that defines inner and outer membranes connected at a pore membrane that …