Opening doors with ultrasound and microbubbles: Beating biological barriers to promote drug delivery

J Deprez, G Lajoinie, Y Engelen, SC De Smedt… - Advanced drug delivery …, 2021 - Elsevier
Apart from its clinical use in imaging, ultrasound has been thoroughly investigated as a tool
to enhance drug delivery in a wide variety of applications. Therapeutic ultrasound, as such …

[HTML][HTML] Repurposing anticancer drugs for the management of COVID-19

K El Bairi, D Trapani, A Petrillo, C Le Page… - European Journal of …, 2020 - Elsevier
Since its outbreak in the last December, coronavirus disease 2019 (COVID-19) caused by
SARS-CoV-2 has rapidly spread worldwide at a pandemic proportion and thus is regarded …

Ciltacabtagene autoleucel, an anti–B-cell maturation antigen chimeric antigen receptor T-cell therapy, for relapsed/refractory multiple myeloma: CARTITUDE-1 2-year …

T Martin, SZ Usmani, JG Berdeja, M Agha… - Journal of Clinical …, 2023 - ascopubs.org
PURPOSE CARTITUDE-1, a phase Ib/II study evaluating the safety and efficacy of
ciltacabtagene autoleucel (cilta-cel) in heavily pretreated patients with relapsed/refractory …

Proteomics and machine learning approaches reveal a set of prognostic markers for COVID-19 severity with drug repurposing potential

K Suvarna, D Biswas, MGJ Pai, A Acharjee… - Frontiers in …, 2021 - frontiersin.org
The pestilential pathogen SARS-CoV-2 has led to a seemingly ceaseless pandemic of
COVID-19. The healthcare sector is under a tremendous burden, thus necessitating the …

A neutrophil extracellular trap-related risk score predicts prognosis and characterizes the tumor microenvironment in multiple myeloma

Z Zhao, Y Huo, Y Du, Y Huang, H Liu, C Zhang… - Scientific Reports, 2024 - nature.com
Multiple myeloma (MM) is a distinguished hematologic malignancy, with existing studies
elucidating its interaction with neutrophil extracellular traps (NETs), which may potentially …

Clinical management of triple-class refractory multiple myeloma: a review of current strategies and emerging therapies

ME Stalker, TM Mark - Current Oncology, 2022 - mdpi.com
Major progress has been made in the upfront treatment of multiple myeloma, but the disease
ultimately relapses and leads to death in the vast majority of those afflicted. New treatment …

Recent advances in the treatment of patients with multiple myeloma

MA Legarda, MJ Cejalvo, J de la Rubia - Cancers, 2020 - mdpi.com
Simple Summary The evolving data from trials assessing novel combinations as a part of the
frontline and relapse treatment in transplant and non-transplant candidates have markedly …

The nuclear pore complex and mRNA export in cancer

KLB Borden - Cancers, 2020 - mdpi.com
Simple Summary There are multiple processes that can go awry to drive cancer. One of
these arises from a dysregulation of trafficking of cellular materials between the two major …

NK cell therapy in relapsed refractory multiple myeloma

E Roshandel, H Ghaffari-Nazari, M Mohammadian… - Clinical …, 2023 - Elsevier
Recent advances in adoptive cell therapy have considerably changed the paradigm of
cancer immunotherapy. Although current immunotherapies could cure many patients with …

Dual targeting of protein translation and nuclear protein export results in enhanced antimyeloma effects

S Li, J Fu, CJ Walker, J Yang, D Bhutani… - Blood …, 2023 - ashpublications.org
Abstract Selinexor (KPT-330) is a small molecule inhibitor of XPO1, which mediates the
transport of tumor suppressor proteins, oncogene messenger RNAs, and other proteins …