Liquid–liquid phase separation (LLPS) is a novel principle for explaining the precise spatial
and temporal regulation in living cells. LLPS compartmentalizes proteins and nucleic acids …

Malignant transformation is characterized by dysregulation of diverse cellular processes that
have been the subject of detailed genetic, biochemical, and structural studies, but only …

Diffuse midline glioma-H3K27M mutant (DMG) and glioblastoma (GBM) are the most lethal
brain tumors that primarily occur in pediatric and adult patients, respectively. Both tumors …

Human endogenous retroviruses (HERVs) are abundant sequences that persist within the
human genome as remnants of ancient retroviral infections. These sequences became fixed …

Recent advances in neoantigen research have accelerated the development and regulatory
approval of tumor immunotherapies, including cancer vaccines, adoptive cell therapy and …

Endometrial cancer (EC) is one of the most common gynecological cancers. Ferroptosis is a
newly identified form of cell death characterized by iron-dependent lipid peroxide …

Precision medicine has greatly aided in improving health outcomes using earlier diagnosis
and better prognosis for chronic diseases. It makes use of clinical data associated with the …

Aberrant alternative pre-mRNA splicing plays a critical role in MYC-driven cancers and
therefore may represent a therapeutic vulnerability. Here, we show that neuroblastoma, a …

Abstract Cyclin D1 (CCND1), a crucial mediator of cell cycle progression, possesses many
mutation types with different mutation frequencies in human cancers. The G870A mutation is …

Aberrant RNA splicing produces alternative isoforms of genes to facilitate tumor progression,
yet how this process is regulated by oncogenic signal remains largely unknown. Here, we …