Combination therapy is increasingly becoming the cornerstone of current day antitumor
therapy. Glioblastoma multiforme is an aggressive brain tumor with a dismal median survival …

Glutathione (GSH) is the predominant low-molecular-weight antioxidant with a ubiquitous
distribution inside the cell. The steady-state level of cellular GSH is dependent on the …

Abnormal metabolism of tumour cells is closely related to the occurrence and development
of breast cancer, during which the expression of NF‐E2‐related factor 2 (Nrf2) is of great …

Evidence has recently emerged on the influence of gender on the immune system. In this
systematic review and meta-analysis of phase III randomized clinical trials (RCTs), we …

Genome instability has been identified as one of the enabling hallmarks in cancer. DNA
damage response (DDR) network is responsible for maintenance of genome integrity in …

Genome editing allows for the precise manipulation of DNA sequences in a cell making this
technology essential for understanding gene function. CRISPR/Cas9 is a targeted genome …

Development requires the careful orchestration of several biological events in order to
create any structure and, eventually, to build an entire organism. On the other hand, the fate …

Background We investigated the role of PD-L1 in the metabolic reprogramming of non-small
cell lung cancer (NSCLC). Methods Changes in glycolysis-related molecules and glycolytic …

Poly (ADP-ribose) polymerase (PARP) inhibitors are a novel class of therapeutic agents that
target tumors with deficiencies in the homologous recombination DNA repair pathway …

Cancer remains one of the most feared and dreaded diseases in this era of modern
medicine, claiming the lives of many, and affecting the quality of life of several others around …