Dual role of TNF and LTα in carcinogenesis as implicated by studies in mice
EO Gubernatorova, AI Polinova, MM Petropavlovskiy… - Cancers, 2021 - mdpi.com
Simple Summary Tumor necrosis factor (TNF) and its closely related cytokine, lymphotoxin
alpha (LTα), are part of the TNF superfamily and exert their functions via both overlapping …
alpha (LTα), are part of the TNF superfamily and exert their functions via both overlapping …
TNFα and immune checkpoint inhibition: Friend or foe for lung cancer?
T Benoot, E Piccioni, K De Ridder… - International Journal of …, 2021 - mdpi.com
Tumor necrosis factor-alpha (TNFα) can bind two distinct receptors (TNFR1/2). The
transmembrane form (tmTNFα) preferentially binds to TNFR2. Upon tmTNFα cleavage by the …
transmembrane form (tmTNFα) preferentially binds to TNFR2. Upon tmTNFα cleavage by the …
Pleiotropic effects of BAFF on the senescence-associated secretome and growth arrest
Senescent cells release a variety of cytokines, proteases, and growth factors collectively
known as the senescence-associated secretory phenotype (SASP). Sustained SASP …
known as the senescence-associated secretory phenotype (SASP). Sustained SASP …
High Expression of TTYH3 Is Related to Poor Clinical Outcomes in Human Gastric Cancer
Ion channels play important roles in regulating various cellular processes and malignant
transformation. Expressions of some chloride channels have been suggested to be …
transformation. Expressions of some chloride channels have been suggested to be …
Expression of intracellular components of the NF-κB alternative pathway (NF-κB2, RelB, NIK and Bcl3) is associated with clinical outcome of NSCLC patients
FID Dimitrakopoulos, AG Antonacopoulou… - Scientific reports, 2019 - nature.com
A growing number of studies has shed light on the role of the NF-κΒ in non-small-cell lung
cancer (NSCLC). To address the significance of major effectors of the NF-κΒ alternative …
cancer (NSCLC). To address the significance of major effectors of the NF-κΒ alternative …
Involvement of inflammatory cytokines and epigenetic modification of the mtTFA complex in T-helper cells of patients' suffering from non-small cell lung cancer and …
Dysregulated inflammatory response plays a crucial role in the pathogenesis of chronic
obstructive pulmonary disease (COPD) and Non-Small cell lung cancer (NSCLC). Hence …
obstructive pulmonary disease (COPD) and Non-Small cell lung cancer (NSCLC). Hence …
Immune infiltration profiling in nonsmall cell lung cancer and their clinical significance: study based on gene expression measurements
F Chen, Y Yang, Y Zhao, L Pei, H Yan - DNA and cell biology, 2019 - liebertpub.com
Immune cell infiltration is associated with the prognosis of cancer. This study focused on the
immune infiltration profiling and their association with survival outcome in nonsmall cell lung …
immune infiltration profiling and their association with survival outcome in nonsmall cell lung …
MAPK10 expression as a prognostic marker of the immunosuppressive tumor microenvironment in human hepatocellular carcinoma
H Li, Y Li, Y Zhang, B Tan, T Huang, J Xiong… - Frontiers in …, 2021 - frontiersin.org
Hepatocellular carcinoma (HCC) remains a devastating malignancy worldwide due to lack
of effective therapy. The immune-rich contexture of HCC tumor microenvironment (TME) …
of effective therapy. The immune-rich contexture of HCC tumor microenvironment (TME) …
Genetic Variations of CD40 and LTβR Genes Are Associated With Increased Susceptibility and Clinical Outcome of Non-Small-Cell Carcinoma Patients
FID Dimitrakopoulos, AG Antonacopoulou… - Frontiers in …, 2021 - frontiersin.org
Background Immune system-related receptors CD40 (tumor necrosis factor receptor
superfamily member 5), BAFFR (tumor necrosis factor receptor superfamily member 13C) …
superfamily member 5), BAFFR (tumor necrosis factor receptor superfamily member 13C) …
Integrated analysis of M2 macrophage-related gene prognostic model and single-cell sequence to predict immunotherapy response in lung adenocarcinoma
M Li, Z Wang, B Huang, M Zhang, C Lin - 2024 - researchsquare.com
Methods GSE26939 and GSE19188 chips were downloaded from the Gene Expression
Omnibus (GEO). Weighted gene co-expression network analysis (WGCNA) and least …
Omnibus (GEO). Weighted gene co-expression network analysis (WGCNA) and least …