Lysosomes are membrane‐enclosed organelles that mediate the intracellular degradation
of macromolecules. They play an essential role in calcium regulation and have emerged as …

Phosphoinositide 3-kinase (PI3K) signaling contributes to a variety of processes, mediating
many aspects of cellular function, including nutrient uptake, anabolic reactions, cell growth …

Arsenic exposure causes nonalcoholic steatohepatitis (NASH). Inflammation is a key
contributor to the pathology of nonalcoholic fatty liver disease (NAFLD), including NASH …

Senescent cells accumulate in various tissues and organs with aging altering surrounding
tissue due to an active secretome, and at least in mice their elimination extends healthy …

Hyperuricemia has become a common metabolic disease, and is a risk factor for multiple
diseases, including chronic kidney disease. Our recent study indicated that following …

Previous studies have shown that oxidative stress-induced inhibition of autophagy plays a
pivotal role in cadmium (Cd)-mediated cytotoxicity in primary rat proximal tubular (rPT) cells …

Autophagy has an important renoprotective function and we recently found that autophagy
inhibition is involved in cadmium (Cd)-induced nephrotoxicity. Here, we aimed to investigate …

DNA methylation, one of the most well-studied epigenetic modifications, is involved in a
wide spectrum of biological processes. Epigenetic mechanisms control cellular morphology …

Although excessive consumption of deep-fried foods is regarded as 1 of the most important
epidemiological factors of lifestyle diseases such as Alzheimer's disease, type 2 diabetes …

Context Icariin (ICA) is the main active ingredient of Epimedium brevicornu Maxim
(Berberidaceae), which is used in the immune, reproductive, neuroendocrine systems, and …