IgGs are essential soluble components of the adaptive immune response that evolved to
protect the body from infection. Compared with other immunoglobulins, the role of IgGs is …

Antibodies are essential components of an adaptive immune response. Immunoglobulin G
(IgG) is the most common type of antibody found in circulation and extracellular fluids …

Although the therapeutic efficacy and commercial success of monoclonal antibodies (mAbs)
are tremendous, the design and discovery of new candidates remain a time and cost …

Recombinant human IgG antibodies (hIgGs) completely devoid of binding to Fcγ receptors
(FcγRs) and complement protein C1q, and thus with abolished immune effector functions …

The tutorial introduces the readers to the fundamentals of antibody pharmacokinetics (PK) in
the context of drug development. Topics covered include an overview of antibody …

Quality by design (QbD) is a global regulatory initiative with the goal of enhancing
pharmaceutical development through the proactive design of pharmaceutical manufacturing …

Anti‐angiogenic therapies using biological molecules that neutralize vascular endothelial
growth factor‐A (VEGF‐A) have revolutionized treatment of retinal vascular diseases …

Alterations in protein structure may have profound effects on biological function. Analytical
techniques that permit characterization of proteins while maintaining their conformational …

Beyond potency, a good developability profile is a key attribute of a biological drug.
Selecting and screening for such attributes early in the drug development process can save …

Serum albumin (SA), the most abundant soluble protein in the body, maintains plasma
oncotic pressure and regulates the distribution of vascular fluid and has a range of other …