Molecular Spies in Action: Genetically Encoded Fluorescent Biosensors Light up Cellular Signals
Cellular function is controlled through intricate networks of signals, which lead to the myriad
pathways governing cell fate. Fluorescent biosensors have enabled the study of these …
pathways governing cell fate. Fluorescent biosensors have enabled the study of these …
[HTML][HTML] Activity-driven synaptic translocation of LGI1 controls excitatory neurotransmission
U Cuhadar, L Calzado-Reyes, C Pascual-Caro… - Cell Reports, 2024 - cell.com
The fine control of synaptic function requires robust trans-synaptic molecular interactions.
However, it remains poorly understood how trans-synaptic bridges change to reflect the …
However, it remains poorly understood how trans-synaptic bridges change to reflect the …
[HTML][HTML] Excitation-Dependent pKa Extends the Sensing Range of Fluorescence Lifetime pH Sensors
EP Haynes, M Canzano, M Tantama - Sensors, 2024 - mdpi.com
Biological activity is strongly dependent on pH, which fluctuates within a variety of neutral,
alkaline, and acidic local environments. The heterogeneity of tissue and subcellular pH has …
alkaline, and acidic local environments. The heterogeneity of tissue and subcellular pH has …
Membrane lipid poly-unsaturation selectively affects ligand induced dopamine D2 receptor internalization
S Sposini, R Baccouch, M Lescuyer… - bioRxiv, 2023 - biorxiv.org
The poly-unsaturation of membrane phospholipids is an important feature for the biophysical
properties of membranes and membrane proteins. In particular, it regulates the function of …
properties of membranes and membrane proteins. In particular, it regulates the function of …
Unbiased quantitative ratiometric measurements in multiphoton microscopy with a generalized model
EM Chaigneau, M Tournissac, S Pfister… - … Microscopy in the …, 2024 - spiedigitallibrary.org
Fluorescent indicators allow the monitoring of physiological parameters in biological tissues
by measuring changes in the brightness of the indicator upon binding of its ligand …
by measuring changes in the brightness of the indicator upon binding of its ligand …
Exploiting threonine sidechains as molecular switches to modulate the fluorescence of genetically encoded biosensors
Rapid and reproducible optical transitions of a fluorescent protein (FP) can be achieved with
a Genetically Encoded Voltage Indicator (GEVI) via manipulation of the membrane potential …
a Genetically Encoded Voltage Indicator (GEVI) via manipulation of the membrane potential …