Atomic Force Microscopy: Mechanosensor and Mechanotransducer for Probing Biological System from Molecules to Tissues

Y Shen, DM Czajkowsky, B Li, J Hu, Z Shao, J Sun - Small, 2025 - Wiley Online Library
Abstract Atomic Force Microscopy (AFM) is a powerful technique with widespread
applications in various scientific fields, including biology. It operates by precisely detecting …

Conformations of Bcs1L undergoing ATP hydrolysis suggest a concerted translocation mechanism for folded iron-sulfur protein substrate

J Zhan, A Zeher, R Huang, WK Tang… - Nature …, 2024 - nature.com
Abstract The human AAA-ATPase Bcs1L translocates the fully assembled Rieske iron-sulfur
protein (ISP) precursor across the mitochondrial inner membrane, enabling respiratory …

Membrane mimetic thermal proteome profiling (MM-TPP) towards mapping membrane protein-ligand dynamics

RS Jandu, M Al-Seragi, H Aoki, M Babu, FVH Duong - bioRxiv, 2024 - biorxiv.org
Integral membrane proteins (IMPs) remain the principal target of small-molecule
therapeutics, and yet modalities towards probing on and off-target hits against this protein …