This review summarises current understanding of how bone is sculpted through adaptive
processes, designed to meet the mechanical challenges it faces in everyday life and athletic …

The purpose of the study was to assess the effects of exercise interventions with different
impact loading characteristics on lumbar spine (LS) and femoral neck (FN) bone mineral …

Sclerostin, the protein product of the Sost gene, is a potent inhibitor of bone formation.
Among bone cells, sclerostin is found nearly exclusively in the osteocytes, the cell type that …

Abstract “Wolff's law” is a concept that has sometimes been misrepresented, and frequently
misunderstood, in the anthropological literature. Although it was originally formulated in a …

Although additive manufacturing has offered substantially new opportunities and flexibility
for fabricating 3D complex lattice structures, effective design of such sophisticated structures …

Mechanical loading presents a potent osteogenic stimulus to bone cells, but bone cells
desensitize rapidly to mechanical stimulation. Resensitization must occur before the cells …

The skeleton shows greatest plasticity to physical activity-related mechanical loads during
youth but is more at risk for failure during aging. Do the skeletal benefits of physical activity …

Exercise during growth results in biologically important increases in bone mineral content
(BMC). The aim of this study was to determine whether the effects of loading were site …

Bone is able to react to changing mechanical demands by adapting its internal
microstructure through bone forming and resorbing cells. This process is called bone …

The cell surface receptor, low-density lipoprotein receptor-related protein 5 (LRP5) is a key
regulator of bone mass. Loss-of-function mutations in LRP5 cause the human skeletal …