Neurotransmitters are molecules that amplify, transmit, and convert signals in cells, having
an essential role in information transmission throughout the nervous system. Hundreds of …

Solute carrier (SLCs) transporters mediate the transport of a broad range of solutes across
biological membranes. Dysregulation of SLCs has been associated with various …

The serotonin transporter (SERT) terminates serotonin signaling by using sodium and
chloride gradients to drive reuptake of serotonin into presynaptic neurons and is the target of …

Human serotine transporter (hSERT) is one of the most influential drug targets, and its
allosteric modulators (eg, escitalopram) have emerged to be the next-generation medication …

Depression is a common mental disorder. The standard medical treatment is the selective
serotonin reuptake inhibitors (SSRIs). All characterized SSRIs are competitive inhibitors of …

Human dopamine transporter (hDAT) regulates the reuptake of extracellular dopamine (DA)
and is an essential therapeutic target for central nervous system (CNS) diseases. The …

Allostery is a universal, biological phenomenon in which orthosteric sites are fine‐tuned by
topologically distal allosteric sites triggered by perturbations, such as ligand binding, residue …

The presynaptic serotonin transporter (SERT) clears extracellular serotonin following
vesicular release to ensure temporal and spatial regulation of serotonergic signalling and …

ABSTRACT Introduction Solute carriers (SLCs) represent the largest group of membrane
transporters in the human genome. They play a central role in controlling the …

The norepinephrine transporter (NET) plays a pivotal role in recycling norepinephrine (NE)
from the synaptic cleft. However, the structures referring to the conformational heterogeneity …