Many are frustrated with the lack of translational progress in the pain field, in which huge
gains in basic science knowledge obtained using animal models have not led to the …

Pain is classically viewed as being mediated solely by neurons, as are other sensory
phenomena. The discovery that spinal cord glia (microglia and astrocytes) amplify pain …

Voltage-gated sodium (Nav) channels initiate action potentials in most neurons, including
primary afferent nerve fibres of the pain pathway. Local anaesthetics block pain through non …

Unlike acute pain that warns us of injury or disease, chronic or persistent pain serves no
adaptive purpose. Though there is no agreed on definition of chronic pain, it is commonly …

Tissue damage, inflammation or injury of the nervous system may result in chronic
neuropathic pain characterised by increased sensitivity to painful stimuli (hyperalgesia), the …

Background Musculoskeletal rehabilitative care and research have traditionally been guided
by a structural pathology paradigm and directed their resources towards the structural …

Mirror-image allodynia is a mysterious phenomenon that occurs in association with many
clinical pain syndromes. Allodynia refers to pain in response to light touch/pressure stimuli …

The cornea is the most densely innervated and sensitive tissue in the body. The cornea is
exclusively innervated by C-and A-delta fibers, including mechano-nociceptors that are …

A vast diversity of salient cues is sensed by numerous classes of primary sensory neurons,
defined by specific neuropeptides, ion channels, or cytoskeletal proteins. Recent evidence …

Objective: To determine whether an fMRI memory encoding task distinguishes among
cognitively normal elderly individuals, patients with mild cognitive impairment (MCI), and …