Rationale: The current hypothesis that human pulmonary alveolarization is complete by 3
years is contradicted by new evidence of alveolarization throughout adolescence in …

This review compares the manner in which physical stress imposed on the parenchyma,
vasculature and thorax and the thoraco-pulmonary interactions, drive both developmental …

Pneumonectomy (PNX) in experimental animals leads to a species-and age-dependent
compensatory growth of the remaining lung lobes. PNX mimics the loss of functional gas …

Background Molecular pathways that regulate alveolar development and adult repair
represent potential therapeutic targets for emphysema. Signalling via retinoic acid (RA) …

In adult canines following major lung resection, the remaining lobes expand asymmetrically,
associated with alveolar tissue regrowth, remodeling, and progressive functional …

Following right pneumonectomy (PNX), the remaining lung expands and its perfusion more
than doubles. Tissue and microvascular mechanical stresses are putative stimuli for …

Following right pneumonectomy (PNX), the remaining lung expands and its perfusion
doubles. Tissue and microvascular mechanical stresses are putative stimuli for initiating …

Major lung resection is a robust model that mimics the consequences of loss-of-functioning
lung units. We previously observed in adult canines, following 42% and 58% lung resection …

Physical forces critically shape thoraco-pulmonary development, growth, and adaptation. In
fetal-to-early postnatal life, the lung and thorax are highly sensitive to mechanical stimuli …

Following pneumonectomy (PNX), two separate mechanical forces act on the remaining
lung: parenchymal stress caused by lung expansion, and microvascular distension and …