Harnessing polymer-derived drug delivery systems for combating inflammatory bowel disease

Y Pu, X Fan, Z Zhang, Z Guo, Q Pan, W Gao… - Journal of Controlled …, 2023 - Elsevier
The inflammatory bowel disease (IBD) is incurable, chronic, recrudescent disorders in the
inflamed intestines. Current clinic treatments are challenged by systemic exposure-induced …

Gut microbiota dysbiosis in systemic lupus erythematosus: novel insights into mechanisms and promising therapeutic strategies

Q Pan, F Guo, Y Huang, A Li, S Chen, J Chen… - Frontiers in …, 2021 - frontiersin.org
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that was traditionally
thought to be closely related to genetic and environmental risk factors. Although treatment …

An AIEgen-based oral-administration nanosystem for detection and therapy of ulcerative colitis via 3D-MSOT/NIR-II fluorescent imaging and inhibiting NLRP3 …

L Sun, J Ouyang, F Zeng, S Wu - Biomaterials, 2022 - Elsevier
Ulcerative colitis is the most prevalent forms of inflammatory bowel diseases and a refractory
autoimmune disease and affects millions of people worldwide. Herein, we develop an oral …

Colon-Targeting Angelica sinensis Polysaccharide Nanoparticles with Dual Responsiveness for Alleviation of Ulcerative Colitis

Y Xu, BW Zhu, R Sun, X Li, D Wu… - ACS Applied Materials & …, 2023 - ACS Publications
Intestinal immune dysfunction and gut microbiota dysbiosis are critically causative factors in
the pathogenesis of ulcerative colitis (UC); however, the current first-line drugs for UC …

ROS-responsive hyaluronic acid hydrogel for targeted delivery of probiotics to relieve colitis

L Huang, J Wang, L Kong, X Wang, Q Li… - International Journal of …, 2022 - Elsevier
Probiotics are generally used as therapeutic intervention in inflammatory bowel disease.
However, the low survival rate in harsh gastrointestinal environment and limited retention in …

Wielding the double-edged sword: Redox drug delivery systems for inflammatory bowel disease

Y Chen, M Shui, Q Yuan, CT Vong, Z Yang… - Journal of Controlled …, 2023 - Elsevier
The etiology of inflammatory bowel disease (IBD) is extremely complex and related to an
excessive immune response that results in the pathologically release of reactive oxygen …

H2S‐Releasing Versatile Montmorillonite Nanoformulation Trilogically Renovates the Gut Microenvironment for Inflammatory Bowel Disease Modulation

T Jin, H Lu, Q Zhou, D Chen, Y Zeng, J Shi… - Advanced …, 2024 - Wiley Online Library
Abnormal activation of the intestinal mucosal immune system, resulting from damage to the
intestinal mucosal barrier and extensive invasion by pathogens, contributes to the …

Nanoparticles loaded with pharmacologically active plant-derived natural products: Biomedical applications and toxicity

S Peng, Y Wang, Z Sun, L Zhao, Y Huang, X Fu… - Colloids and Surfaces B …, 2023 - Elsevier
Pharmacologically active natural products have played a significant role in the history of
drug development. They have acted as sources of therapeutic drugs for various diseases …

A Biomarker‐Responsive Nanosystem with Colon‐Targeted Delivery for Ulcerative Colitis's Detection and Treatment with Optoacoustic/NIR‐II Fluorescence Imaging

Z Zeng, J Ouyang, L Sun, F Zeng… - Advanced Healthcare …, 2022 - Wiley Online Library
Ulcerative colitis (UC) is a prevalent idiopathic inflammatory disease which causes such
complications as intestinal perforation, obstruction, and bleeding, and thus deleteriously …

[HTML][HTML] Reactive oxygen species-sensitive materials: A promising strategy for regulating inflammation and favoring tissue regeneration

J Zhou, C Fang, C Rong, T Luo, J Liu… - Smart Materials in …, 2023 - Elsevier
Reactive oxygen species (ROS), acting as essential mediators in the biological system,
highly influence the physiologic and pathologic processes of the human body. The aberrant …