Glioblastoma is the most malignant tumor occurring in the human central nervous system
with overall median survival time< 14.6 months. Current treatments such as chemotherapy …

Endoplasmic reticulum (ER) stress disrupts among others protein homeostasis in cells
leading to the activation of the unfolded protein response (UPR) that is crucial for restoring …

Glioblastoma multiforme (GBM) may be one of the most challenging brain tumors to treat, as
patients generally do not live more than 2 years. This review aimed to give a timely review of …

Gliomas are the most frequent type of tumor in the central nervous system, which exhibit
properties that make their treatment difficult, such as cellular infiltration, heterogeneity, and …

Intracranial malignancies, such as primary brain cancers and brain-localized metastases
derived from peripheral cancers, are particularly difficult to treat with therapeutic agents …

Tumors are one of the most serious human diseases and cause numerous global deaths per
year. In spite of many strategies applied in tumor therapy, such as radiation therapy …

The alkylating agent temozolomide (TMZ) is the first-line chemotherapeutic for glioblastoma
(GBM), a common and aggressive primary brain tumor in adults. However, its poor stability …

Perillyl alcohol (POH) is a naturally occurring monoterpenoid related to limonene that is
present in the essential oils of various plants. It has diverse applications and can be found in …

Simple Summary Acute myeloid leukemia (AML) is a cancer of the blood and bone marrow,
where cancer cells are unable to complete the maturation process towards white blood cells …

As the endothelial-to-mesenchymal transition (EndMT) supports the pro-angiogenic and
invasive characteristics of glioblastoma multiforme (GBM), blocking this process would be a …