Following Milstein's discovery, the monoclonal antibodies (mAbs) became a basic tool for
biomedical science. In cancer field, since the first mAb was approved by the FDA a great …

Simple Summary Early diagnosis and treatment of cancer is crucial for the survival of cancer
patients. Pathologists can use computational pathology techniques to make the diagnosis …

ErbB2 overexpression identifies a subclass of breast cancer as ErbB2-positive that is
frequently associated with poor prognosis. Current ErbB2-targeted therapies have …

ERBB2 abnormalities frequently occur and serve as rationale therapeutic targets in cancer.
In this study, clinical and next-generation sequencing data from 14,956 patients across more …

Simple Summary Early detection and personalized treatment for breast cancer are vital for
breast cancer patients survival. Computational pathology approaches can be employed by …

HER2 assessment is necessary for patient selection in anti-HER2 targeted treatment.
However, manual assessment of HER2 amplification is time-costly, labor-intensive, highly …

Introduction: Pertuzumab is a recombinant, humanized monoclonal antibody that binds to
the dimerization domain of human epidermal growth factor receptor 2 (HER2), inhibiting the …

We focus on drug repurposing in the Ras signaling pathway, considering structural
similarities of protein–protein interfaces. The interfaces formed by physically interacting …

Simple Summary Overexpressed ErbB2/HER2 receptor drives up to a quarter of breast
cancers. One aspect of ErbB2 biology that is poorly understood is how it reaches the cell …

AIM: The aim of this study was to validate the role of fluorescence in situ hybridization (FISH)
in investigating HER2/neu gene amplification (human epidermal growth factor receptor 2) in …