Wnt/β-catenin signaling has been broadly implicated in human cancers and experimental
cancer models of animals. Aberrant activation of Wnt/β-catenin signaling is tightly linked with …

WNT signaling is an elaborate and complex collection of signal transduction pathways
mediated by multiple signaling molecules. WNT signaling is critically important for …

Wnt proteins modulate cell proliferation and differentiation and the self-renewal of stem cells
by inducing β-catenin-dependent signalling through the Wnt receptor frizzled (FZD) and the …

Wnts are lipid-modified morphogens that play critical roles in development principally
through engagement of Frizzled receptors. The 3.25 angstrom structure of Xenopus Wnt8 …

Frizzled and LRP5/6 are Wnt receptors that upon activation lead to stabilization of
cytoplasmic β-catenin. In this study, we review the current knowledge of these two families of …

Wnt signaling regulates a variety of cellular processes, including cell fate, differentiation,
proliferation and stem cell pluripotency. Aberrant Wnt signaling is a hallmark of many …

Wnt genes and components of Wnt signalling pathways have been implicated in a wide
spectrum of important biological phenomena, ranging from early organismal development to …

Inhibition of the Wnt antagonist sclerostin increases bone mass in patients with osteoporosis
and in preclinical animal models. Here we show increased levels of the Wnt antagonist …

Wnt signaling plays critical roles in development of various organs and pathogenesis of
many diseases, and augmented Wnt signaling has recently been implicated in mammalian …

The low-density lipoprotein (LDL) receptor-related protein 2 (LRP2 or megalin) is
representative of the phylogenetically conserved subfamily of giant LDL receptor-related …