Psoriasis is a chronic, immune-mediated, inflammatory disease that is pathogenically driven
by proinflammatory cytokines. This article reviews the immunologic role of interleukin (IL)-17 …

Psoriasis vulgaris is a common, heterogeneous, chronic inflammatory skin disease
characterized by thickened, red, scaly plaques and systemic inflammation. Psoriasis is also …

Summary Whether interleukin-17A (IL-17A) has pathogenic and/or protective roles in the gut
mucosa is controversial and few studies have analyzed specific cell populations for …

Summary T helper 17 (Th17) cells are pathogenic in many inflammatory diseases, but also
support the integrity of the intestinal barrier in a non-inflammatory manner. It is unclear what …

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal
tract with a multifactorial pathophysiology. Full comprehension of IBD pathology is still out of …

IL-17, a potent proinflammatory cytokine, has been shown to intimately contribute to the
formation, growth, and metastasis of a wide range of malignancies. Recent studies implicate …

Dysregulated Th17 cell responses underlie multiple inflammatory and autoimmune
diseases, including autoimmune uveitis and its animal model, EAU. However, clinical trials …

Th17 cells play a critical role in host defense against extracellular pathogens and tissue
homeostasis but can induce autoimmunity. The mechanisms implicated in balancing" …

Background Ankylosing spondylitis is a chronic immune-mediated inflammatory disease
characterised by spinal inflammation, progressive spinal rigidity, and peripheral arthritis …

Targeting cytokines in inflammatory bowel disease (IBD) is a useful clinical approach.
Potential therapies for IBD include regulatory T cell transfer to restore cytokine balance …