Over the last few decades, hot melt extrusion (HME) has emerged as a successful
technology for a broad spectrum of applications in the pharmaceutical industry. As indicated …

Abstract Metal-organic framework (MOF)-based composite hydrogel microspheres
(MOF/hydrogel) are one of the most promising adsorbents for high-efficiency wastewater …

Posterior segment diseases, such as age-related macular degeneration (AMD) and diabetic
retinopathy (DR) are vital factor that seriously threatens human vision health and quality of …

Bacterial keratitis (BK) is a critical ocular infection that can lead to serious visual disability.
Ciprofloxacin (CIP), moxifloxacin (MOX), and levofloxacin (LFX) have been accepted as …

Background Voriconazole (VRC) is a triazole broad spectrum antifungal drug, used in the
management of versatile fungal infections, particularly fungal keratitis. The obligatory use of …

The present investigation was intended to formulate and evaluate a hot-melt extruded (HME)
bioadhesive ophthalmic inserts containing a fixed-dose combination of Prednisolone …

Delivery of therapeutic molecules into the deeper ocular compartments is mainly hampered
by short precorneal residence and limited transmembrane permeability of topically …

Currently, ocular inserts and nanoparticles have received much attention due to the limited
bioavailability of conventional eye preparations and the toxicity problems of systemic drug …

Short precorneal residence time and poor transocular membrane permeability are the major
challenges associated with topical ocular drug delivery. In the present research, the …

Objectives Efficacy and compliance of type II diabetes treatment would greatly benefit from
dosage forms providing controlled release of metformin in the upper gastrointestinal tract. In …