[HTML][HTML] Differentiation of Sinoatrial-like Cardiomyocytes as a Biological Pacemaker Model
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are widely used
for disease modeling and pharmacological screening. However, their application has mainly …
for disease modeling and pharmacological screening. However, their application has mainly …
[HTML][HTML] Calcium handling abnormalities increase arrhythmia susceptibility in DMSXL myotonic dystrophy type 1 mice
Background Myotonic dystrophy type 1 (DM1) is a multiorgan disorder with significant
cardiac involvement. ECG abnormalities, including arrhythmias, occur in 80% of DM1 …
cardiac involvement. ECG abnormalities, including arrhythmias, occur in 80% of DM1 …
Impacts of DCM-Linked Gating Pore Currents on the Electrophysiological Characteristics of hiPSC-CM Monolayers
Background Variants of the SCN5A gene, which encodes the Na V 1.5 cardiac sodium
channel, have been linked to arrhythmic disorders associated with dilated cardiomyopathy …
channel, have been linked to arrhythmic disorders associated with dilated cardiomyopathy …
Exploring SCN5A variants associated with atrial fibrillation in atrial cardiomyocytes derived from human induced pluripotent stem cells: A characterization study
Background Atrial fibrillation (AF) poses a major risk for heart failure, myocardial infarction,
and stroke. Several studies have linked SCN5A variants to AF, but their precise mechanistic …
and stroke. Several studies have linked SCN5A variants to AF, but their precise mechanistic …