The nervous system comprises a remarkably diverse and complex network of different cell
types, which must communicate with one another with speed, reliability, and precision. Thus …

Microglia are the resident immune cells and phagocytes of our central nervous system
(CNS). While most work has focused on the rapid and robust responses of microglia during …

Synapses between engram cells are believed to be substrates for memory storage, and the
weakening or loss of these synapses leads to the forgetting of related memories. We found …

Microglia are the immune cells of the brain. In the absence of pathological insult, their highly
motile processes continually survey the brain parenchyma and transiently contact synaptic …

Brain circuits undergo substantial structural changes during development, driven by the
formation, stabilization, and elimination of synapses. Synaptic connections continue to …

Recent studies have provided long-sought evidence that behavioural learning involves
specific synapse gain and elimination processes, which lead to memory traces that influence …

Plasticity is a basic process that underlies neural and cognitive functioning, unraveling thus
the former's pervasive role in development and learning. Plasticity processes operate in both …

The shift in ocular dominance (OD) of binocular neurons induced by monocular deprivation
is the canonical model of synaptic plasticity confined to a postnatal critical period …

Synapses are the fundamental units of neuronal circuits. Synaptic plasticity can occur
through changes in synaptic strength, as well as through the addition/removal of synapses …

Background The extracellular matrix (ECM) of the brain is rich in glycosaminoglycans such
as chondroitin sulfate (CS) and hyaluronan. These glycosaminoglycans are organized into …