Proton beam therapy (PBT) offers significant benefit over conventional (photon) radiotherapy
for the treatment of a number of different human cancers, largely due to the physical …

Radiobiological modelling has been a key part of radiation biology and therapy for many
decades, and many aspects of clinical practice are guided by tools such as the linear …

The linear-quadratic model is one of the key tools in radiation biology and physics. It
provides a simple relationship between cell survival and delivered dose:, and has been …

The TOPAS Monte Carlo (MC) system is used in radiation therapy and medical imaging
research, having played a significant role in making Monte Carlo simulations widely …

FLASH radiotherapy delivers a high dose (≥ 10 Gy) at a high rate (≥ 40 Gy/s). In this way,
particles are delivered in pulses as short as a few nanoseconds. At that rate, intertrack …

Our understanding of radiation-induced cellular damage has greatly improved over the past
few decades. Despite this progress, there are still many obstacles to fully understand how …

Variations in the intrinsic radiosensitivity of different cells to ionizing radiation is now widely
believed to be a significant driver in differences in response to radiotherapy. While the …

Radiotherapy has played an essential role in cancer treatment for over a century, and
remains one of the best-studied methods of cancer treatment. Because of its close links with …

The cellular response to ionizing radiation continues to be of significant research interest in
cancer radiotherapy, and DNA is recognized as the critical target for most of the biologic …

There is agreement that high-LET radiation has a high Relative Biological Effectiveness
(RBE) when delivered as a single treatment, but how it interacts with radiations of different …