The polymorphic nature of the cytochrome P450 (CYP) genes affects individual drug
response and adverse reactions to a great extent. This variation includes copy number …

Pharmacogenetics is the study of how interindividual variations in the DNA sequence of
specific genes affect drug response. This article highlights current pharmacogenetic …

Cytochrome P450 2B6 (CYP2B6) belongs to the minor drug metabolizing P450s in human
liver. Expression is highly variable both between individuals and within individuals, owing to …

Objectives: Efavirenz is an effective antiretroviral agent, but central nervous system side
effects occur commonly, and population (racial) differences in pharmacokinetics and …

The cytochrome P450s are responsible for about 75% of phase I dependent drug
metabolism and for the metabolism of a huge amount of dietary constituents and …

Background Efavirenz (EFV) and nevirapine (NVP) are metabolized by cytochrome P450
2B6 (CYP2B6). Allele 516 G> T (Gln172His) is associated with diminished activity of this …

Ethnopharmacological relevance Herb–drug interactions are of great concern in health
practices. Curcumin is a natural polyphenol extracted from turmeric, a spice widely used all …

Genistein is an isoflavone present in soy and is known to have multiple molecular effects,
such as the inhibition of inflammation, promotion of apoptosis, and modulation of steroidal …

Drug metabolism studies constitute an important and necessary step in the evaluation of
drug efficacy and safety. In vivo drug metabolism studies suffer from many disadvantages …

Polymorphisms in drug-metabolizing enzymes and drug transporters contribute to wide and
inheritable variability in drug pharmacokinetics, response and toxicity. One of the less well …