CD4 helper and CD8 cytotoxic T cell differentiation
I Taniuchi - Annual review of Immunology, 2018 - annualreviews.org
A fundamental question in developmental immunology is how bipotential thymocyte
precursors generate both CD4+ helper and CD8+ cytotoxic T cell lineages. The MHC …
precursors generate both CD4+ helper and CD8+ cytotoxic T cell lineages. The MHC …
RUNX transcription factors: orchestrators of development
ABSTRACT RUNX transcription factors orchestrate many different aspects of biology,
including basic cellular and developmental processes, stem cell biology and tumorigenesis …
including basic cellular and developmental processes, stem cell biology and tumorigenesis …
Steroid-resistant human inflammatory ILC2s are marked by CD45RO and elevated in type 2 respiratory diseases
EK van der Ploeg, K Golebski, M van Nimwegen… - Science …, 2021 - science.org
Group 2 innate lymphoid cells (ILC2s) orchestrate protective type 2 immunity and have been
implicated in various immune disorders. In the mouse, circulatory inflammatory ILC2s …
implicated in various immune disorders. In the mouse, circulatory inflammatory ILC2s …
TCRαβ+ CD3+ CD4− CD8−(double negative) T cells in autoimmunity
D Brandt, CM Hedrich - Autoimmunity reviews, 2018 - Elsevier
Abstract TCRαβ+ CD3+ CD4− CD8−“double negative”(DN) T cells comprise a small subset
of mature peripheral T cells. The origin and function of DN T cells are somewhat unclear and …
of mature peripheral T cells. The origin and function of DN T cells are somewhat unclear and …
Runx transcription factors in t cells—what is beyond thymic development?
S Korinfskaya, S Parameswaran, MT Weirauch… - Frontiers in …, 2021 - frontiersin.org
Runx proteins (also known as Runt-domain transcription factors) have been studied for a
long time as key regulators of cellular differentiation. RUNX2 has been described as …
long time as key regulators of cellular differentiation. RUNX2 has been described as …
Essential roles of SATB1 in specifying T lymphocyte subsets
K Kakugawa, S Kojo, H Tanaka, W Seo, TA Endo… - Cell reports, 2017 - cell.com
T cell receptor (TCR) signaling by MHC class I and II induces thymocytes to acquire cytotoxic
and helper fates via the induction of Runx3 and ThPOK transcription factors, respectively …
and helper fates via the induction of Runx3 and ThPOK transcription factors, respectively …
Cytotoxic CD4 T cells: differentiation, function, and application to dengue virus infection
Dengue virus (DENV) has spread through most tropical and subtropical areas of the world
and represents a serious public health problem. The control of DENV infection has not yet …
and represents a serious public health problem. The control of DENV infection has not yet …
CD4+ T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2
N Boucheron, R Tschismarov, L Goeschl… - Nature …, 2014 - nature.com
Molecular mechanisms that maintain lineage integrity of helper T cells are largely unknown.
Here we show histone deacetylases 1 and 2 (HDAC1 and HDAC2) as crucial regulators of …
Here we show histone deacetylases 1 and 2 (HDAC1 and HDAC2) as crucial regulators of …
cAMP responsive element modulator (CREM) α mediates chromatin remodeling of CD8 during the Generation of CD3+ CD4− CD8− T cells
TCR-αβ+ CD3+ CD4− CD8−" double negative" T cells are expanded in the peripheral blood
of patients with systemic lupus erythematosus (SLE) and lupus-prone mice. Double negative …
of patients with systemic lupus erythematosus (SLE) and lupus-prone mice. Double negative …
CD4–CD8 differentiation in the thymus: connecting circuits and building memories
Y Xiong, R Bosselut - Current opinion in immunology, 2012 - Elsevier
The proper choice of the CD4-helper or CD8-cytotoxic lineages by developing T cells is
crucial for the generation of an antigen-responsive and functionally fit T cell repertoire. Here …
crucial for the generation of an antigen-responsive and functionally fit T cell repertoire. Here …