Leigh syndrome is the most common pediatric presentation of mitochondrial disease. This
neurodegenerative disorder is genetically heterogeneous, and to date pathogenic mutations …

Leigh syndrome (LS) is the most common pediatric presentation of a defined mitochondrial
disease. This progressive encephalopathy is characterized pathologically by the …

Cellular activity in the brain depends on the high energetic support provided by
mitochondria, the cell organelles which use energy sources to generate ATP,,,. Acute …

Leigh syndrome (LS) is a severe manifestation of mitochondrial disease in children and is
currently incurable. The lack of effective models hampers our understanding of the …

Membrane-bound organelles such as mitochondria, peroxisomes, or the endoplasmic
reticulum (ER) create distinct environments to promote specific cellular tasks such as ATP …

Apolipoprotein E ɛ4 allele is a common susceptibility gene for late-onset Alzheimer's
disease. Brain vascular and metabolic deficits can occur in cognitively normal …

Advancing age is the top risk factor for the development of neurodegenerative disorders,
including Alzheimer's disease (AD). However, the contribution of aging processes to AD …

Cytochrome c oxidase (COX) is the terminal enzyme of the electron transport chain and
catalyzes the transfer of electrons from cytochrome c to oxygen. COX consists of 14 subunits …

After shock, persistent oxygen extraction deficit despite the apparent adequate recovery of
systemic hemodynamic and oxygen-derived variables has been a source of uncertainty and …

Many factors contribute to the health risks encountered by astronauts on missions outside
Earth's atmosphere. Spaceflight-induced potential adverse neurovascular damage and late …