T cells and natural killer (NK) cells have complementary roles in tumor immunity, and dual T
cell and NK cell attack thus offers opportunities to deepen the impact of immunotherapy …

When cells undergo necrotic cell death in either physiological or pathophysiological settings
in vivo, they release highly immunogenic intracellular molecules and organelles into the …

The past few decades have witnessed the rise of immunotherapy for Gastrointestinal (GI)
tract cancers. The role of immune checkpoint inhibitors (ICIs), particularly programmed death …

Eukaryotic cells react to potentially dangerous perturbations of the intracellular or
extracellular microenvironment by activating rapid (transcription-independent) mechanisms …

Upon solid organ transplantation and during cancer immunotherapy, cellular stress
responses result in the release of damage-associated molecular patterns (DAMPs). The …

Ovarian cancer (OC) is diagnosed in~ 22,000 women in the US each year and kills 14,000
of them. Often, patients are not diagnosed until the later stages of disease, when treatment …

Burkholderia pseudomallei is the causative agent of melioidosis, an infectious disease in the
tropics and subtropics with high morbidity and mortality. The facultative intracellular …

Simple Summary The immune system provides surveillance measures to identify and
remove damaged cell types at an early stage. One important example involves the NKG2D …

The pathophysiological importance of the immunogenicity of damage-associated molecular
patterns (DAMPs) has been pinpointed by their identification as triggers of allograft rejection …

Natural killer (NK) cells recognize and kill cancer cells and infected cells by engaging cell
surface ligands that are induced preferentially or exclusively on these cells. These ligands …