Hepatocellular carcinoma (HCC) is an aggressive disease with a poor clinical outcome. The
cancer stem cell (CSC) model states that tumour growth is powered by a subset of tumour …

Tumorigenesis is a highly complex process, involving many interrelated and cross-acting
signalling pathways. One such pathway that has garnered much attention in the field of …

YAP and TAZ are highly related transcriptional regulators pervasively activated in human
malignancies. Recent work indicates that, remarkably, YAP/TAZ are essential for cancer …

Yes-associated protein (YAP) and TAZ (WW domain containing transcription regulator 1, or
WWTR1) are paralog transcriptional regulators, able to integrate mechanical, metabolic, and …

A distinctive feature of cancer cells of various origins involves alterations of the composition
of lipids, with significant enrichment in monounsaturated fatty acids. These molecules, in …

The Hippo signaling pathway, also known as the Salvador− Warts− Hippo pathway, is a
regulator of organ size. The pathway takes its name from the Drosophila protein kinase …

Liver cancer is an often fatal malignant tumor with a high recurrence rate and
chemoresistance. The major malignant phenotypes of cancer, including recurrence …

Yes-associated protein (YAP) and its paralog, transcriptional coactivator with PDZ-binding
motif (TAZ), play pivotal roles in promoting the progression of hepatocellular carcinoma …

Recent evidences suggest that stearoyl-CoA-desaturase 1 (SCD1), the enzyme involved in
monounsaturated fatty acids synthesis, has a role in several cancers. We previously …

Pancreatic ductal adenocarcinoma (PDAC) is generally a fatal disease with no efficacious
treatment modalities. Elucidation of signaling mechanisms that will lead to the identification …