In vivo two-photon calcium imaging (2PCI) is a technique used for recording neuronal
activity in the intact brain. It is based on the principle that, when neurons fire action …

Intravital microscopy is increasingly used to visualize and quantitate dynamic biological
processes at the (sub) cellular level in live animals. By visualizing tissues through imaging …

Ischemic stroke is an acute and severe neurological disease, resulting in disability and
death. Reperfusion to an ischemic brain is a means to reverse brain damage after stroke; …

Cranial window implants in head-fixed rodents are becoming a preparation of choice for
stable optical access to large areas of the cortex over extended periods of time. Here we …

We present functional ultrasound (fUS), a method for imaging transient changes in blood
volume in the whole brain at better spatiotemporal resolution than with other functional brain …

Pericytes are essential for normal brain function, but many aspects of their physiology
remain enigmatic due to a lack of tools to genetically target this cell population. Here, we …

Background Craniotomy-based window implants are commonly used for microscopic
imaging, in head-fixed rodents, however their field of view is typically small and incompatible …

Near-infrared fluorescence (NIRF) molecular imaging has been widely applied to monitoring
therapy of cancer and other diseases in preclinical studies; however, this technology has not …

Alzheimer's disease (AD) is a neurodegenerative disorder in which vascular pathology plays
an important role. Since the β-amyloid peptide (Aβ) is a critical factor in this disease, we …

Fragile X syndrome (FXS) causes mental impairment and autism through transcriptional
silencing of the Fmr1 gene, resulting in the loss of the RNA-binding protein fragile X mental …