The ability to regulate and even target mutagenesis is an extremely valuable cellular asset.
Enzyme-catalyzed DNA cytosine deamination is a molecular strategy employed by …

Several members of the APOBEC3 family of cellular restriction factors provide intrinsic
immunity to the host against viral infection. Specifically, APOBEC3DE, APOBEC3F …

Successful intracellular pathogens must evade or neutralize the innate immune defenses of
their host cells and render the cellular environment permissive for replication. For example …

The human apolipoprotein B mRNA-editing enzyme catalytic polypeptide–like 3 (APOBEC3,
referred to as A3) proteins are cellular cytidine deaminases that potently restrict retrovirus …

APOBEC3 (A3) genes are members of the AID/APOBEC gene family that are found
exclusively in mammals. A3 genes encode antiviral proteins that restrict the replication of …

The APOBEC3 restriction factors are a family of deoxycytidine deaminases that are able to
suppress replication of viruses with a single-stranded DNA intermediate by inducing …

Retroviruses have an intricate life cycle. There is much to be learned from studying retrovirus-
host interactions. Among retroviruses, the primate lentiviruses have one of the more complex …

Human APOBEC3F is an antiretroviral single-strand DNA cytosine deaminase, susceptible
to degradation by the HIV-1 protein Vif. In this study the crystal structure of the HIV Vif …

Abstract The human APOBEC3G (A3G) DNA cytosine deaminase restricts and hypermutates
DNA-based parasites including HIV-1. The viral infectivity factor (Vif) prevents restriction by …

The human APOBEC3 family of DNA cytosine deaminases serves as a front-line intrinsic
immune response to inhibit the replication of diverse retroviruses. APOBEC3F and …