The repeated intense stimulation of skeletal muscle rapidly decreases its force-and motion-
generating capacity. This type of fatigue can be temporally correlated with the accumulation …

The depression in force and/or velocity associated with muscular fatigue can be the result of
a failure at any level, from the initial events in the motor cortex of the brain to the formation of …

Intrinsically disordered regions (IDRs) are essential for membrane receptor regulation but
often remain unresolved in structural studies. TRPV4, a member of the TRP vanilloid …

Numerous biological processes, including muscular contraction, depend upon the
mechanical properties of actin filaments. One such property is resistance to bending (flexural …

Mechanical properties of adherent cells were investigated using methods of engineering
mechanics. The cytoskeleton (CSK) was modeled as a filamentous network and key …

The cause of muscle fatigue has been studied for more than 100 yr, yet its molecular basis
remains poorly understood. Prevailing theories suggest that much of the fatigue-induced …

We have used high-speed video microscopy to measure in vivo length oscillations of the
indirect flight muscles of the fruit fly Drosophila virilis during tethered flight. The changes in …

The optical micromanipulation systems UV (ultraviolet)-Laser Microbeam and Optical
Tweezers Trap, already proven to be powerful tools for 'non-contact'micro-manipulation of …

Apicomplexa is a large phylum of intracellular parasites that are notable for the diseases
they cause, including toxoplasmosis, malaria, and cryptosporidiosis. A conserved motile …

Smooth muscle contraction is due to the interaction of myosin filaments with thin filaments.
Thin filaments are composed of actin, tropomyosin, caldesmon and calmodulin in ratios 14∶ …