Genomic and epigenomic aberrations in esophageal squamous cell carcinoma and implications for patients
DC Lin, MR Wang, HP Koeffler - Gastroenterology, 2018 - Elsevier
Esophageal squamous cell carcinoma (ESCC) is a common malignancy without effective
therapy. The exomes of more than 600 ESCCs have been sequenced in the past 4 years …
therapy. The exomes of more than 600 ESCCs have been sequenced in the past 4 years …
Non-receptor protein tyrosine kinases signaling pathways in normal and cancer cells
Protein tyrosine kinases (PTKs) are enzymes that transfer phosphate groups to tyrosine
residues on protein substrates. Phosphorylation of proteins causes changes in their function …
residues on protein substrates. Phosphorylation of proteins causes changes in their function …
Dissecting esophageal squamous-cell carcinoma ecosystem by single-cell transcriptomic analysis
Esophageal squamous-cell carcinoma (ESCC), one of the most prevalent and lethal
malignant disease, has a complex but unknown tumor ecosystem. Here, we investigate the …
malignant disease, has a complex but unknown tumor ecosystem. Here, we investigate the …
A CD90+ Tumor-Initiating Cell Population with an Aggressive Signature and Metastatic Capacity in Esophageal Cancer
Abstract Tumor-initiating cells (TIC), also known as cancer stem cells, are regarded widely
as a specific subpopulation of cells needed for cancer initiation and progression. TICs have …
as a specific subpopulation of cells needed for cancer initiation and progression. TICs have …
FSTL1 promotes metastasis and Chemoresistance in esophageal squamous cell carcinoma through NFκB–BMP signaling cross-talk
Esophageal squamous cell carcinoma (ESCC) has a generally poor prognosis, and
molecular markers to improve early detection and predict outcomes are greatly needed …
molecular markers to improve early detection and predict outcomes are greatly needed …
Transcriptome sequencing identifies ANLN as a promising prognostic biomarker in bladder urothelial carcinoma
S Zeng, X Yu, C Ma, R Song, Z Zhang, X Zi, X Chen… - Scientific Reports, 2017 - nature.com
The prognosis of bladder urothelial carcinoma (BLCA) varies greatly even for patients with
similar pathological characteristics. We conducted transcriptome sequencing on ten pairs of …
similar pathological characteristics. We conducted transcriptome sequencing on ten pairs of …
A novel 3p22. 3 gene CMTM7 represses oncogenic EGFR signaling and inhibits cancer cell growth
Abstract Deletion of 3p12-22 is frequent in multiple cancer types, indicating the presence of
critical tumor-suppressor genes (TSGs) at this region. We studied a novel candidate TSG …
critical tumor-suppressor genes (TSGs) at this region. We studied a novel candidate TSG …
Understanding the cellular roles of Fyn-related kinase (FRK): implications in cancer biology
The non-receptor tyrosine kinase Fyn-related kinase (FRK) is a member of the BRK family
kinases (BFKs) and is distantly related to the Src family kinases (SFKs). FRK was first …
kinases (BFKs) and is distantly related to the Src family kinases (SFKs). FRK was first …
PTK6 inhibits autophagy to promote uveal melanoma tumorigenesis by binding to SOCS3 and regulating mTOR phosphorylation
B Liu, X Yao, C Zhang, Y Liu, L Wei, Q Huang… - Cell Death & …, 2023 - nature.com
Autophagy dysfunction is one of the common causes of tumor formation and plays an
important role in uveal melanoma (UM). However, little is known about the regulatory …
important role in uveal melanoma (UM). However, little is known about the regulatory …
Neuropilin‐2 promotes tumourigenicity and metastasis in oesophageal squamous cell carcinoma through ERK–MAPK–ETV4–MMP–E‐cadherin deregulation
TM Fung, KY Ng, M Tong, JN Chen… - The Journal of …, 2016 - Wiley Online Library
Oesophageal squamous cell carcinoma (ESCC) is the most common histological subtype of
oesophageal cancer. The disease is particularly prevalent in southern China. The incidence …
oesophageal cancer. The disease is particularly prevalent in southern China. The incidence …