Arthritic Microenvironment‐Dictated Fate Decisions for Stem Cells in Cartilage Repair

S He, H Deng, P Li, J Hu, Y Yang, Z Xu, S Liu… - Advanced …, 2023 - Wiley Online Library
The microenvironment and stem cell fate guidance of post‐traumatic articular cartilage
regeneration is primarily the focus of cartilage tissue engineering. In articular cartilage, stem …

MicroRNAs and long non-coding RNAs in cartilage homeostasis and osteoarthritis

J Gu, W Rao, S Huo, T Fan, M Qiu, H Zhu… - Frontiers in Cell and …, 2022 - frontiersin.org
During the last decade, osteoarthritis (OA) has become one of the most prevalent
musculoskeletal diseases worldwide. OA is characterized by progressive loss of articular …

FTO-mediated m6A demethylation of pri-miR-3591 alleviates osteoarthritis progression

W Liu, T Jiang, W Zheng, J Zhang, A Li, C Lu… - Arthritis Research & …, 2023 - Springer
Objectives Increasing evidence have demonstrated the N6-methyladenosine (m6A) plays
critical roles in osteoarthritis (OA) progression, but the role of m6A in OA has not been …

LncRNA WDR11-AS1 promotes extracellular matrix synthesis in osteoarthritis by directly interacting with RNA-binding protein PABPC1 to stabilize SOX9 expression

H Huang, J Yan, X Lan, Y Guo, M Sun, Y Zhao… - International Journal of …, 2023 - mdpi.com
Osteoarthritis (OA) is a degenerative disease of articular cartilage that is mainly
characterized by chronic and mild inflammation of the joints. Recently, many studies have …

LncRNA AC006064. 4–201 serves as a novel molecular marker in alleviating cartilage senescence and protecting against osteoarthritis by destabilizing CDKN1B …

P Shen, J Gao, S Huang, C You, H Wang, P Chen… - Biomarker …, 2023 - Springer
Background Osteoarthritis (OA) is the most prevalent age-related disease in the world.
Chondrocytes undergo an age-dependent decline in their proliferation and synthetic …

The emerging role of lncRNAs in osteoarthritis development and potential therapy

X Zhang, Q Liu, J Zhang, C Song, Z Han, J Wang… - Frontiers in …, 2023 - frontiersin.org
Osteoarthritis impairs the functions of various joints, such as knees, hips, hands and spine,
which causes pain, swelling, stiffness and reduced mobility in joints. Multiple factors …

[HTML][HTML] Osteoarthritis year in review 2022: Genetics, genomics and epigenetics

M Kim, A Rubab, WCW Chan, D Chan - Osteoarthritis and Cartilage, 2023 - Elsevier
This “year in review” provides a summary of the research findings on the topic of genetics,
genomics and epigenetics for osteoarthritis (OA) between Mar 2021–Apr 2022. A search …

Emerging role of lncRNAs in osteoarthritis: An updated review

R Wang, HT Shiu, WYW Lee - Frontiers in immunology, 2022 - frontiersin.org
Osteoarthritis (OA) is a prevalent joint disease, which is associated with progressive articular
cartilage loss, synovial inflammation, subchondral sclerosis and meniscus injury. The …

RMRP accelerates ligamentum flavum hypertrophy by regulating GSDMD-mediated pyroptosis through Gli1 SUMOylation

X Yan, T Liu, R Zhang, Q Ma, C Sun - Frontiers in Immunology, 2024 - frontiersin.org
Hypertrophy of ligamentum flavum (LF) is a significant contributing factor to lumbar spinal
canal stenosis (LSCS). lncRNA plays a vital role in organ fibrosis, but its role in LF fibrosis …

Unraveling the Molecular Landscape of Osteoarthritis: A Comprehensive Review Focused on the Role of Non-Coding RNAs

M Shakeri, A Aminian, K Mokhtari, M Bahaeddini… - … -Research and Practice, 2024 - Elsevier
Osteoarthritis (OA) poses a significant global health challenge, with its prevalence
anticipated to increase in the coming years. This review delves into the emerging molecular …