Extracellular matrixes (ECMs) are intricate 3-dimensional macromolecular networks of
unique architectures with regulatory roles in cell morphology and functionality. As a dynamic …

The tumor microenvironment is a complex structure composed of the extracellular matrix
(ECM) and nontumoral cells (notably cancer-associated fibroblasts (CAFs) and immune …

Vascular smooth muscle cell (vSMC) is highly plastic as its phenotype can change in
response to mechanical cues inherent to the extracellular matrix (ECM). VSMC may be …

Background Immune exclusion (IE) where tumors deter the infiltration of immune cells into
the tumor microenvironment has emerged as a key mechanism underlying immunotherapy …

As pancreatic cancer is the third deadliest cancer in the US, the ability to study genetic
alterations is necessary to provide further insight into potentially targetable regions for …

Discoidin domain receptors (DDR1 and DDR2) are the collagen receptors of the family
tyrosine kinases, which play significant role in the diseases like inflammation, fibrosis and …

Simple Summary Colorectal cancer (CRC) is the third leading cause of cancer death in both
sexes. Identification of the influencing factors and molecular mechanisms in CRC …

Pregnancy has a dual effect on the risk of breast cancer. On one hand, pregnancy at a
young age is known to be protective. However, pregnancy is also associated with a transient …

The migration ability of urothelial carcinoma corresponding to dismal prognosis had not
been fully investigated. The interaction of extracellular collagen with a unique …

Despite significant discoveries in basic cancer research and improvements in treatment
options and clinical outcomes, cancer remains a major public health concern worldwide …