[HTML][HTML] Heme Oxygenase-1 and Prostate Cancer: Function, Regulation, and Implication in Cancer Therapy

RJ Salloom, IM Ahmad, DZ Sahtout, MJ Baine… - International Journal of …, 2024 - mdpi.com
Prostate cancer (PC) is a significant cause of mortality in men worldwide, hence the need for
a comprehensive understanding of the molecular mechanisms underlying its progression …

[HTML][HTML] PROTACs targeting androgen receptor signaling: potential therapeutic agents for castration-resistant prostate cancer

Y Zhang, A Ming, J Wang, W Chen, Z Fang - Pharmacological Research, 2024 - Elsevier
After the initial androgen deprivation therapy (ADT), part of the prostate cancer may
continuously deteriorate into castration-resistant prostate cancer (CRPC). The majority of …

Oncogenic potential of truncated-Gli3 via the Gsk3β/Gli3/AR-V7 axis in castration-resistant prostate cancer

JB Kaushal, P Raut, S Halder, ZW Alsafwani, S Parte… - Oncogene, 2025 - nature.com
The functional activation of the androgen receptor (AR) and its interplay with the aberrant
Hh/Gli cascade are pivotal in the progression of castration-resistant prostate cancer (CRPC) …

Reynoutria multiflora (Thunb.) Moldenke and its ingredient suppress lethal prostate cancer growth by inducing CDC25B-CDK1 mediated cell cycle arrest

Q Zhou, F Wu, Y Chen, J Fu, L Zhou, Y Xu, F He… - Bioorganic …, 2024 - Elsevier
Abstract Background Reynoutria multiflora (Thunb.) Moldenke (Polygonum multiflorum
Thunb, PM) is a medicinal plant that was an element of traditional Chinese medicine (TCM) …

Second generation androgen receptor antagonist, TQB3720 abrogates prostate cancer growth via AR/GPX4 axis activated ferroptosis

Z Zhang, T Xie, S Zhang, H Yin, X Zhang… - Frontiers in …, 2023 - frontiersin.org
Purpose: Prostate cancer (PCa) poses a great threat to humans. The study aimed to
evaluate the potential of TQB3720 in promoting ferroptosis to suppress prostate cancer …

Combination of miR-99b-5p and Enzalutamide or Abiraterone Synergizes the Suppression of EMT-Mediated Metastasis in Prostate Cancer

M Waseem, BD Wang - Cancers, 2024 - mdpi.com
Simple Summary To date, effective treatment for metastatic prostate cancer (PCa) remains a
clinical challenge. Our previous study demonstrated that tumor suppressive miR-99b-5p …

[HTML][HTML] Prostate cancer research: tools, cell types, and molecular targets

AY Liu - Frontiers in Oncology, 2024 - frontiersin.org
Multiple cancer cell types are found in prostate tumors. They are either luminal-like
adenocarcinoma or less luminal-like and more stem-like non-adenocarcinoma and small …

Lathyrol reduces the RCC invasion and incidence of EMT via affecting the expression of AR and SPHK2 in RCC mice

S Song, L Tai, Y Xu, J Jiang, L Zhou, J Zhao - Discover Oncology, 2024 - Springer
Objective To investigate the effects of Lathyrol on the expression of androgen receptor (AR)
and sphingosine kinase 2 (SPHK2) in renal cell carcinoma (RCC) mice and to further …

Ligand‐gated ion channels as potential biomarkers for ADT‐mediated cognitive decline in prostate cancer patients

S Verma, V Singh, VK Nagampalli… - Molecular …, 2024 - Wiley Online Library
Men with prostate cancer are at increased risk of developing cognitive decline by the use of
second‐generation androgen signaling inhibitors. To date, reliable and sensitive biomarkers …

Effects of androgenic modulation on the morphophysiology of the adrenal cortex of male gerbils

V Grigio, SB Silva, TFR Ruiz… - Molecular and Cellular …, 2024 - Elsevier
The study aimed to investigate the repercussions of androgen modulation on the adrenal
cortex of male gerbils, focusing on the morphophysiology, proliferation, and cell death, as …