Lipid peroxidation in atherosclerotic cardiovascular diseases

E Gianazza, M Brioschi… - Antioxidants & redox …, 2021 - liebertpub.com
Significance: Atherosclerotic cardiovascular diseases (ACVDs) continue to be a primary
cause of mortality worldwide in adults aged 35–70 years, occurring more often in countries …

Recent advances in analytical methods of oxidative stress biomarkers induced by environmental pollutant exposure

X Zhou, S Gao, M Yue, S Zhu, Q Liu, XE Zhao - TrAC Trends in Analytical …, 2023 - Elsevier
Exposure to environmental pollutants poses a great threat to human health. Oxidative stress
is one of the widely accepted toxicity mechanisms of pollutants, and oxidative stress …

Oxidative stress and reproductive function: The impact of oxidative stress on reproduction: A focus on gametogenesis and fertilization

RJ Aitken, EG Bromfield, Z Gibb - Reproduction, 2022 - rep.bioscientifica.com
In brief Many aspects of the reproductive process are impacted by oxidative stress. This
article summarizes the chemical nature of reactive oxygen species and their role in both the …

A nanoreactor boosts chemodynamic therapy and ferroptosis for synergistic cancer therapy using molecular amplifier dihydroartemisinin

XX Yang, X Xu, MF Wang, HZ Xu, XC Peng… - Journal of …, 2022 - Springer
Background Chemodynamic therapy (CDT) relying on intracellular iron ions and H2O2 is a
promising therapeutic strategy due to its tumor selectivity, which is limited by the not enough …

Chemical sensors for imaging total cellular aliphatic aldehydes in live cells

R Wills, J Farhi, P Czabala, S Shahin, JM Spangle… - Chemical …, 2023 - pubs.rsc.org
Aliphatic aldehydes are reactive electrophilic carbonyls that cross-link with DNA and
proteins leading to cellular toxicity and disease pathogenesis. This toxicity is due to the …

4-Hydroxy-2-nonenal, a lipid peroxidation product, as a biomarker in diabetes and its complications: Challenges and opportunities

D Dham, B Roy, A Gowda, G Pan, A Sridhar… - Free radical …, 2021 - Taylor & Francis
Over 30 million Americans are diagnosed with diabetes and this number is only expected to
increase. There are various causes that induce complications with diabetes, including …

Derivatization procedures and their analytical performances for HPLC determination in bioanalysis

V David, SC Moldoveanu… - Biomedical …, 2021 - Wiley Online Library
Derivatization, or chemical structure modification, is often used in bioanalysis performed by
liquid chromatography technique in order to enhance detectability or to improve the …

Solid-Phase Reactivity-Directed Extraction (SPREx): an alternative approach for simultaneous extraction, identification, and prioritization of toxic electrophiles …

DN Grace, MN Newmeyer, C Prasse - ACS Environmental Au, 2024 - ACS Publications
Current strategies to assess water quality are ineffective at prioritizing the most toxic
chemicals within a treated water sample. Although it is well known that oxidation byproducts …

Analysis of reactive aldehydes in urine and plasma of type-2 diabetes mellitus patients through liquid chromatography-mass spectrometry: reactive aldehydes as …

C Harkin, D Cobice, J Watt, MJ Kurth… - Frontiers in …, 2023 - frontiersin.org
Introduction Diabetes is a major public health issue that is approaching epidemic
proportions globally. Diabetes mortality is increasing in all ethnic groups, irrespective of …

Tunable fluorescent probes for detecting aldehydes in living systems

R Wills, R Shirke, H Hrncir, JM Talbott, K Sad… - Chemical …, 2024 - pubs.rsc.org
Aldehydes, pervasive in various environments, pose health risks at elevated levels due to
their collective toxic effects via shared mechanisms. Monitoring total aldehyde content in …