Mycobacterium tuberculosis (Mtb) is one of the most important infectious agents worldwide
and causes more than 1.5 million deaths annually. To make matters worse, the drug …

Parasitic diseases still compromise human health. Some of the currently available
therapeutic drugs have limitations considering their adverse effects, questionable efficacy …

Hijacking the cellular protein degradation system offers unique opportunities for drug
discovery, as exemplified by proteolysis-targeting chimeras. Despite their great promise for …

Summary The ClpC1: ClpP1P2 protease is a core component of the proteostasis system in
mycobacteria. To improve the efficacy of antitubercular agents targeting the Clp protease …

An emerging interest for the application of periodate in the synthesis of active
pharmaceutical ingredients (APIs) and for the valorization of renewable feedstock is …

Apratoxin A and B, two members of an interesting class of marine cyclodepsipeptides are
synthesized in a straightforward manner via Matteson homologation. Starting from a chiral …

Antimicrobial resistance is a global health threat that requires the development of new
treatment concepts. These should not only overcome existing resistance but be designed to …

Ilamycins/rufomycins are marine cycloheptapeptides containing unusual amino acids.
Produced by Streptomyces sp., these compounds show potent activity against a range of …

Ilamycins/rufomycins and cyclomarins are marine cycloheptapeptides containing unusual
amino acids. Produced by Streptomyces sp., these compounds show potent activity against …

The exploitation of natural products and their analogues in the field of pharmacology has
been regarded as of great importance. It can be attributed to the fact that these scaffolds …