Simple Summary Acquired resistance to molecularly targeted therapies remains a major
challenge in the treatment of cancer. It has been hypothesized that drug-tolerant (or …

Activating mutations in the epidermal growth factor receptor gene occur as early cancer-
driving clonal events in a subset of patients with non-small cell lung cancer (NSCLC) and …

Although many drugs/treatments are now available for most diseases, too often, resistance
to these treatments impedes complete therapeutic success. Acquired resistance is a major …

Non-genetic mechanisms have recently emerged as important drivers of anticancer drug
resistance. Among these, the drug tolerant persister (DTP) cell phenotype is attracting more …

Cell identity is largely determined by its transcriptional profile. In tumour, deregulation of
transcription factor expression and/or activity enables cancer cell to acquire a stem-like state …

Cancer drug resistance and epithelial-mesenchymal transition (EMT), a critical process of
cancer invasion and metastasis, have recently been associated with the existence of cancer …

Ferroptosis is a novel type of regulated cell death, whose unique metabolic characteristics
are commonly used to evaluate the conditions of various diseases especially in tumors …

Cancer stem cells (CSC) constitute a small area of the tumor mass and are characterized by
self-renewal, differentiation and the ability to promote the development of secondary chemo …

Breast cancer (BC) is one of the most common malignant tumors in women globally, and its
occurrence has surpassed lung cancer and become the biggest threat for women. At …

Cancer stem cells (CSCs) are considered as a small population of cells with stem-like
properties within the tumor bulk, and are largely responsible for tumor recurrence …