Xpert® MTB/RIF assay for pulmonary tuberculosis and rifampicin resistance in adults

KR Steingart, H Sohn, I Schiller… - Cochrane database …, 2013 - cochranelibrary.com
Background Accurate and rapid detection of tuberculosis (TB) and drug resistance are
critical for improving patient care and decreasing the spread of TB. Xpert® MTB/RIF assay …

Drug-resistant tuberculosis: a persistent global health concern

M Farhat, H Cox, M Ghanem, CM Denkinger… - Nature Reviews …, 2024 - nature.com
Drug-resistant tuberculosis (TB) is estimated to cause 13% of all antimicrobial resistance-
attributable deaths worldwide and is driven by both ongoing resistance acquisition and …

Feasibility, accuracy, and clinical effect of point-of-care Xpert MTB/RIF testing for tuberculosis in primary-care settings in Africa: a multicentre, randomised, controlled …

G Theron, L Zijenah, D Chanda, P Clowes, A Rachow… - The Lancet, 2014 - thelancet.com
Summary Background The Xpert MTB/RIF test for tuberculosis is being rolled out in many
countries, but evidence is lacking regarding its implementation outside laboratories, ability to …

Xpert Ultra versus Xpert MTB/RIF for pulmonary tuberculosis and rifampicin resistance in adults with presumptive pulmonary tuberculosis

JS Zifodya, JS Kreniske, I Schiller… - Cochrane Database …, 2021 - cochranelibrary.com
Background Xpert MTB/RIF and Xpert MTB/RIF Ultra (Xpert Ultra) are World Health
Organization (WHO)‐recommended rapid tests that simultaneously detect tuberculosis and …

Impact of replacing smear microscopy with Xpert MTB/RIF for diagnosing tuberculosis in Brazil: a stepped-wedge cluster-randomized trial

B Durovni, V Saraceni, S van den Hof, A Trajman… - PLoS …, 2014 - journals.plos.org
Background Abundant evidence on Xpert MTB/RIF accuracy for diagnosing tuberculosis
(TB) and rifampicin resistance has been produced, yet there are few data on the population …

Accuracy and impact of Xpert MTB/RIF for the diagnosis of smear-negative or sputum-scarce tuberculosis using bronchoalveolar lavage fluid

G Theron, J Peter, R Meldau, H Khalfey, P Gina… - Thorax, 2013 - thorax.bmj.com
Rationale The accuracy and impact of new tuberculosis (TB) tests, such as Xpert MTB/RIF,
when performed on bronchoalveolar lavage fluid (BALF) obtained from patients with sputum …

Anti-tuberculosis drug resistance among new and previously treated sputum smear-positive tuberculosis patients in Uganda: results of the first national survey

D Lukoye, F Adatu, K Musisi, GW Kasule, W Were… - PloS one, 2013 - journals.plos.org
Background Multidrug resistant and extensively drug resistant tuberculosis (TB) have
become major threats to control of tuberculosis globally. The rates of anti-TB drug resistance …

Time to treatment and patient outcomes among TB suspects screened by a single point-of-care xpert MTB/RIF at a primary care clinic in Johannesburg, South Africa

CF Hanrahan, K Selibas, CB Deery, H Dansey… - PloS one, 2013 - journals.plos.org
Introduction In December 2010, the World Health Organization recommended a single Xpert
MTB/RIF assay as the initial diagnostic in people suspected of HIV-associated or drug …

Impact of the GeneXpert MTB/RIF technology on tuberculosis control

WS Stevens, L Scott, L Noble, N Gous… - Microbiology …, 2017 - Am Soc Microbiol
Molecular technology revolutionized the diagnosis of tuberculosis (TB) with a paradigm shift
to faster, more sensitive, clinically relevant patient care. The most recent molecular leader is …

Effects of introducing Xpert MTB/RIF on diagnosis and treatment of drug-resistant tuberculosis patients in Indonesia: a pre-post intervention study

SC Van Kampen, NH Susanto, S Simon, SD Astiti… - PloS one, 2015 - journals.plos.org
Background In March 2012, the Xpert MTB/RIF assay (Xpert) was introduced in three
provincial public hospitals in Indonesia as a novel diagnostic to detect tuberculosis and …