Sex-specific genetic architecture of human disease
Sexual dimorphism in anatomical, physiological and behavioural traits are characteristics of
many vertebrate species. In humans, sexual dimorphism is also observed in the prevalence …
many vertebrate species. In humans, sexual dimorphism is also observed in the prevalence …
What are maternal effects (and what are they not)?
Maternal effects can play an important role in a diversity of ecological and evolutionary
processes such as population dynamics, phenotypic plasticity, niche construction, life-history …
processes such as population dynamics, phenotypic plasticity, niche construction, life-history …
Epigenetics and the placenta
ECM Nelissen, APA van Montfoort… - Human reproduction …, 2011 - academic.oup.com
BACKGROUND The placenta is of utmost importance for intrauterine fetal development and
growth. Deregulation of placentation can lead to adverse outcomes for both mother and …
growth. Deregulation of placentation can lead to adverse outcomes for both mother and …
The landscape of genomic imprinting across diverse adult human tissues
Genomic imprinting is an important regulatory mechanism that silences one of the parental
copies of a gene. To systematically characterize this phenomenon, we analyze tissue …
copies of a gene. To systematically characterize this phenomenon, we analyze tissue …
Genomic imprinting and parent-of-origin effects on complex traits
Parent-of-origin effects occur when the phenotypic effect of an allele depends on whether it
is inherited from the mother or the father. Several phenomena can cause parent-of-origin …
is inherited from the mother or the father. Several phenomena can cause parent-of-origin …
Epigenome dynamics: a quantitative genetics perspective
Classically, quantitative geneticists have envisioned DNA sequence variants as the only
source of heritable phenotypes. This view should be revised in light of accumulating …
source of heritable phenotypes. This view should be revised in light of accumulating …
Snord116 is critical in the regulation of food intake and body weight
Y Qi, L Purtell, M Fu, NJ Lee, J Aepler, L Zhang… - Scientific reports, 2016 - nature.com
Prader-Willi syndrome (PWS) is the predominant genetic cause of obesity in humans.
Recent clinical reports have suggested that micro-deletion of the Snord116 gene cluster can …
Recent clinical reports have suggested that micro-deletion of the Snord116 gene cluster can …
[HTML][HTML] The architecture of parent-of-origin effects in mice
The number of imprinted genes in the mammalian genome is predicted to be small, yet we
show here, in a survey of 97 traits measured in outbred mice, that most phenotypes display …
show here, in a survey of 97 traits measured in outbred mice, that most phenotypes display …
Hormonally mediated increases in sex-biased gene expression accompany the breakdown of between-sex genetic correlations in a sexually dimorphic lizard
The evolution of sexual dimorphism is predicted to occur through reductions in between-sex
genetic correlations (r mf) for shared traits, but the physiological and genetic mechanisms …
genetic correlations (r mf) for shared traits, but the physiological and genetic mechanisms …
Epigenetic and genetic components of height regulation
Adult height is a highly heritable trait. Here we identified 31.6 million sequence variants by
whole-genome sequencing of 8,453 Icelanders and tested them for association with adult …
whole-genome sequencing of 8,453 Icelanders and tested them for association with adult …