DNA must be accurately copied and propagated from one cell division to the next, and from
one generation to the next. To ensure the faithful transmission of the genome, a plethora of …

The heterogeneous species of tRNA-derived fragments (tRFs) with specific biological
functions was recently identified. Distinct roles of tRFs in tumor development and viral …

Meiotic chromosome segregation relies on programmed DNA double-strand break
induction. These are in turn repaired by homologous recombination, generating physical …

Defects in crossover (CO) formation during meiosis are a leading cause of birth defects,
embryonic lethality, and infertility. In a wide range of species, maternal aging increases …

Purpose To investigate the expression and underlying mechanism of RPA2 in endometrium
of patients with repeated implantation failure (RIF). Methods In this study, we retrieved the …

Abstract 53BP1 plays a crucial role in regulating DNA damage repair pathway choice and
checkpoint signaling in somatic cells; however, its role in meiosis has remained enigmatic …

Nonsteroidal anti-inflammatory drugs (NSAIDs) have become contaminants widely
distributed in the environment due to improper disposal and discharge. Previous study has …

Tardigrades are known for their ability to survive remarkable extremes, but relatively little is
known about the molecular underpinnings that allow for their extraordinary stress tolerance …

CBL0137 is a lead drug for human African trypanosomiasis, caused by Trypanosoma brucei.
Herein, we use a four-step strategy to 1) identify physiologic targets and 2) determine modes …

Homologous recombination (HR) plays a critical role in largely error-free repair of mitotic
and meiotic DNA double-strand breaks (DSBs). DSBs are one of the most deleterious DNA …