Potential biomarkers for the early prediction of SARS-COV-2 disease outcome

V Mariappan, PS Manoharan, R Pajanivel… - Microbial …, 2021 - Elsevier
The current pandemic due to the fast spreading of SARS-CoV-2 infection has caused severe
impairment in health, social, economic, scientific, and medical sectors across the globe …

[HTML][HTML] Neutralizing the free radicals could alleviate the disease severity following an infection by positive strand RNA viruses

AB Pillai, AR JeanPierre, V Mariappan… - Cell Stress and …, 2022 - Elsevier
Free radical release due to oxidative stress is gaining importance in the field of viral
pathogenesis. Recent studies suggest the involvement of oxidative stress and ROS levels in …

Infection of endothelial cells by dengue virus induces ROS production by different sources affecting virus replication, cellular activation, death and vascular …

LM Meuren, EB Prestes, MP Papa… - Frontiers in …, 2022 - frontiersin.org
Exacerbated inflammatory response and altered vascular function are hallmarks of dengue
disease. Reactive oxygen species (ROS) production has been associated to endothelial …

[HTML][HTML] Hepatoprotective, antioxidant, anti-inflammatory, and antiviral activities of silymarin against mayaro virus infection

AC Ferraz, LT Almeida, CC da Silva Caetano… - Antiviral Research, 2021 - Elsevier
Infection caused by Mayaro virus (MAYV) is responsible for causing acute nonspecific fever,
in which the majority of patients develop incapacitating and persistent arthritis/arthralgia …

[HTML][HTML] Zika virus induces oxidative stress and decreases antioxidant enzyme activities in vitro and in vivo

LT Almeida, AC Ferraz, CC da Silva Caetano… - Virus research, 2020 - Elsevier
The first outbreak of Zika virus (ZIKV) infection in the Americas, especially in Brazil, was
reported in 2015. Fever, headache, rash, and conjunctivitis are the common symptoms of …

Enteroviral 2B interacts with VDAC3 to regulate reactive oxygen species generation that is essential to viral replication

ML Cheng, CH Wu, KY Chien, CH Lai, GJ Li, YY Liu… - Viruses, 2022 - mdpi.com
Enterovirus (EV) 71 caused episodes of outbreaks in China and Southeast Asia during the
last few decades. We have previously reported that EV71 induces reactive oxygen species …

Oropouche virus infection induces ROS production and oxidative stress in liver and spleen of mice

MB da Silva Menegatto, AC Ferraz… - Journal of General …, 2023 - microbiologyresearch.org
Oropouche virus (OROV) is the aetiological agent of Oropouche fever, the symptoms of
which are common to most arboviruses, such as fever, headache, malaise, nausea and …

Yellow fever virus infection in human hepatocyte cells triggers an imbalance in redox homeostasis with increased reactive oxygen species production, oxidative stress …

AC Ferraz, MB da Silva Menegatto, RLS Lima… - Free Radical Biology …, 2024 - Elsevier
Yellow fever (YF) presents a wide spectrum of severity, with clinical manifestations in
humans ranging from febrile and self-limited to fatal cases. Although YF is an old disease for …

Grape seed proanthocyanidins inhibit replication of the dengue virus by targeting NF-kB and MAPK-mediated cyclooxygenase-2 expression

WC Chen, M Hossen, W Liu, CH Yen, CH Huang… - Viruses, 2023 - mdpi.com
Dengue virus (DENV) infection is a serious global health issue as it causes severe dengue
hemorrhagic fever and dengue shock syndrome. Since no approved therapies are available …

Oxygen sensing and viral replication: implications for tropism and pathogenesis

PJ Liu, P Balfe, JA McKeating, M Schilling - Viruses, 2020 - mdpi.com
The ability to detect and respond to varying oxygen tension is an essential prerequisite to
life. Several mechanisms regulate the cellular response to oxygen including the prolyl …