The hallmark of tumorigenesis is the successful circumvention of cell death regulation for
achieving unlimited replication and immortality. Ferroptosis is a newly identified type of cell …

The M1/M2 macrophage paradigm plays a key role in tumor progression. M1 macrophages
are historically regarded as anti-tumor, while M2-polarized macrophages, commonly …

Macrophages are present in all vertebrate tissues, from mid-gestation throughout life,
constituting a widely dispersed organ system. They promote homeostasis by responding to …

A major hallmark of cancer is successful evasion of regulated forms of cell death. Ferroptosis
is a recently discovered type of regulated necrosis which, unlike apoptosis or necroptosis, is …

The lymphatic system is comprised of a network of vessels interrelated with lymphoid tissue,
which has the holistic function to maintain the local physiologic environment for every cell in …

The tumor microenvironment is a complex ecology of cells that evolves with and provides
support to tumor cells during the transition to malignancy. Among the innate and adaptive …

Macrophages are distributed in tissues throughout the body and contribute to both
homeostasis and disease. Recently, it has become evident that most adult tissue …

Despite the advances that have been made in developing new therapeutics, cardiovascular
disease remains the leading cause of worldwide mortality. Therefore, understanding the …

Myocardial infarction (MI) leads to cardiomyocyte death, which triggers an immune response
that clears debris and restores tissue integrity. In the adult heart, the immune system …

The purpose of immunology is simple. Cure or prevent disease. M1/M2 is useful because it
is simple. M1/M2 describes the two major and opposing activities of macrophages. M1 …