The therapeutic journey of benzimidazoles: A review

Y Bansal, O Silakari - Bioorganic & medicinal chemistry, 2012 - Elsevier
Presence of benzimidazole nucleus in numerous categories of therapeutic agents such as
antimicrobials, antivirals, antiparasites, anticancer, anti-inflammatory, antioxidants, proton …

Structure–activity relationship analysis of benzimidazoles as emerging anti-inflammatory agents: An overview

R Veerasamy, A Roy, R Karunakaran, H Rajak - Pharmaceuticals, 2021 - mdpi.com
A significant number of the anti-inflammatory drugs currently in use are becoming obsolete.
These are exceptionally hazardous for long-term use because of their possible unfavourable …

Benzimidazole: an emerging scaffold for analgesic and anti-inflammatory agents

M Gaba, S Singh, C Mohan - European journal of medicinal chemistry, 2014 - Elsevier
Within the vast range of heterocycles, benzimidazole and its derivatives are found to be
trendy structures employed for discovery of drugs in the field of pharmaceutical and …

[HTML][HTML] Greener organic synthetic methods: Sonochemistry and heterogeneous catalysis promoted multicomponent reactions

IV Machado, JRN Dos Santos, MAP Januario… - Ultrasonics …, 2021 - Elsevier
Ultrasound is an essential technique to improve organic synthesis from the point of view of
green chemistry, as it can promote better yields and selectivities, in addition to shorter …

[HTML][HTML] Benzimidazoles: A biologically active compounds

M Shaharyar, A Mazumder - Arabian Journal of Chemistry, 2017 - Elsevier
Synthesis of commercially available benzimidazole involves condensation of o-
phenylenediamine with formic acid. The most prominent benzimidazole compound in nature …

Design, synthesis and ADMET prediction of bis-benzimidazole as anticancer agent

M Rashid - Bioorganic chemistry, 2020 - Elsevier
A new series of bis-benzimidazole clubbed with primary amine (3i-iii) and aromatic
aldehydes (4i-ix) were design and synthesize with an intention to search an anticancer lead …

Synthesis of benzimidazoles bearing oxadiazole nucleus as anticancer agents

M Rashid, A Husain, R Mishra - European journal of medicinal chemistry, 2012 - Elsevier
Starting from 4-(1H-benzo [d] imidazol-2-yl)-4-oxobutanehydrazide (1), twenty new 1-(1H-
benzo [d] imidazol-2-yl)-3-(1, 3, 4-oxadiazol-5-substituted derivatives-2-yl) propan-1-ones …

Recent advancements on benzimidazole: A versatile scaffold in medicinal chemistry

ZMM Alzhrani, MM Alam… - Mini Reviews in Medicinal …, 2022 - ingentaconnect.com
Benzimidazole is a nitrogen-containing fused heterocycle which has been extensively
explored in medicinal chemistry. Benzimidizole nucleus has been found to possess various …

Functionalized benzimidazole scaffolds: privileged heterocycle for drug design in therapeutic medicine

OO Ajani, DV Aderohunmu, CO Ikpo… - Archiv der …, 2016 - Wiley Online Library
Benzimidazole derivatives are crucial structural scaffolds found in diverse libraries of
biologically active compounds which are therapeutically useful agents in drug discovery and …

Microwave-assisted synthesis of N-heterocycles in medicinal chemistry

D Garella, E Borretto, A Di Stilo, K Martina… - …, 2013 - pubs.rsc.org
The syntheses of almost all N-heterocycles have now been successfully performed under
microwave irradiation and have provided significant improvements in the reaction time and …