The primary reason for high mortality rates among cancer patients is metastasis, where
tumor cells migrate through the bloodstream from the original site to other parts of the body …

Targeted therapy and immunotherapy have revolutionized cancer treatment. However, the
ability of cancer to evade the immune system remains a major barrier for effective treatment …

Background & Aims The therapeutic effect of immune checkpoint inhibitors (ICIs) is poor in
hepatocellular carcinoma (HCC) and varies greatly among individuals. Schlafen (SLFN) …

Patients diagnosed with epithelial ovarian cancer (OC) have a 5-year survival rate of 49%.
For early-stage disease, the 5-year survival rate is above 90%. However, advanced-stage …

DNA methylation profiles are in dynamic equilibrium via the initiation of methylation,
maintenance of methylation and demethylation, which control gene expression and …

Simple Summary ctDNA is a small DNA fragment derived from tumor cells, which contains
tumor-related genomic information, such as mutation, methylation, microsatellite instability …

DNA methylation is a fundamental mechanism of epigenetic control in cells and its
dysregulation is strongly implicated in cancer development. Cancers possess an extensively …

Aberrant DNA hypermethylation at regulatory cis-elements of particular genes is seen in a
plethora of pathological conditions including cardiovascular, neurological, immunological …

Abstract Objectives Circulating tumor DNA (ctDNA) is emerging as a potential prognostic
biomarker in multiple tumor types. However, despite the many studies available on small …

Background Ovarian cancer is a highly aggressive malignancy with limited therapeutic
options and a poor prognosis. Deubiquitinating enzymes (DUBs) have emerged as critical …