A future-oriented approach is the application of Digital Twins for process development,
optimization and finally during manufacturing. Digital Twins are detailed virtual …

Process control and optimization is important in ensuring a process in sustaining profitable
income while maintaining the required quality. The fermentation process has attracted …

Bioprocesses are involved in producing different pharmaceutical products. Complicated
dynamics, nonlinearity and non-stationarity make controlling them a very delicate task. The …

Soft sensors are used widely to estimate a process variable which is difficult to measure
online. One of the crucial difficulties of soft sensors is that predictive accuracy drops due to …

This study was focused on the prediction and optimization of biogas production from cow
manure with maize straw under various total solid content (TS), Carbon to Nitrogen (C/N) …

The exploitation of dynamic process conditions increasingly finds attention for strain
screening and bioprocess development of biotechnological products. Prerequisite for …

Teaching-learning-based optimization (TLBO) is a recently proposed meta-heuristic
optimization method and demonstrates outstanding performance for solving numerous …

Biotechnological processes–particularly fermentation processes-play a very important
technological an economical role for the production steps in the food and beverage sector …

Reliable control of the specific growth rate (μ) in fed-batch fermentations depends on the
availability of accurate online estimations of the controlled variable. Due to difficulties in …

Understanding the growth characteristics of microorganisms is an essential step in
bioprocessing, not only because product formation may be growth-associated but also …