Biodegradable materials, including natural and synthetic polymers and hydrolyzable metals,
constitute the main components of temporary, implantable medical devices. Besides the …

Tissue injury triggers a complex series of cellular responses, starting from inflammation
activated by tissue and cell damage and proceeding to healing. By clearing cell debris …

Mitochondrial dysfunction and oxidative stress damage are hallmarks of osteoarthritis (OA).
Mesenchymal stem cell (MSC)-derived exosomes are important in intercellular mitochondria …

Numerous surgical procedures are daily performed worldwide to replace and repair
damaged tissue. Tissue engineering is the field devoted to the regeneration of damaged …

Extracellular matrix (ECM) collectively represents a class of naturally derived proteinaceous
biomaterials purified from harvested organs and tissues with increasing scientific focus and …

The multidisciplinary fields of tissue engineering and regenerative medicine have the
potential to revolutionize the practise of medicine through the abilities to repair, regenerate …

This review analyzes the literature of bone grafts and introduces tissue engineering as a
strategy in this field of orthopedic surgery. We evaluated articles concerning bone grafts; …

The host response to biomaterials has been studied for decades. Largely, the interaction of
host immune cells, macrophages in particular, with implanted materials has been …

The extracellular matrix (ECM) is a meshwork of both structural and functional proteins
assembled in unique tissue-specific architectures. The ECM both provides the mechanical …

Macrophages have been classified as having plastic phenotypes which exist along a
spectrum between M1 (classically activated; pro-inflammatory) and M2 (alternatively …